Russian Journal of Genetics

, Volume 43, Issue 3, pp 338–340 | Cite as

Evolution of genome size: A phylogenetic test of the DNA loss hypothesis

  • M. R. Pie
Short Communications


It has been recently suggested that the C-value paradox, the lack of an obvious association between organismal complexity and genome size, can result simply from biases in insertion and deletion rates—the DNA loss hypothesis. This hypothesis has been heavily criticized, particularly because its evidence, a negative relationship between genome size and DNA loss rate, is based on a highly selective use of the available data. In this study it is shown that the even the most favorable interpretation of the data favoring the DNA loss hypothesis is largely an artifact of phylogenetic nonindependence, supporting the assertion made by other authors that the mechanisms underlying genome size evolution might be more complex than envisioned by the DNA loss hypothesis.


Genome Size Organismal Complexity Obvious Association Base Pair Substitution Deletion Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Pleiades Publishing, Inc. 2007

Authors and Affiliations

  • M. R. Pie
    • 1
  1. 1.Departamento de ZoologiaUniversidade Federal do ParanáCuritibaBrazil

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