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Association between high activity of DNA polymerase iota and the development of human uveal melanoma

  • Human Genetics
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Abstract

Enzymatic activity of DNA polymerase iota (Pol ι) was analyzed in human uveal melanoma cell extracts, using an earlier elaborated approach. The Pol ι activity was observed in seven out of eight malignant tumors, while it was absent in the normal uveal tract cells of the same patients. These findings serve as an additional confirmation of the Pol ι oncogenic potential.

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Authors and Affiliations

  1. Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, 123182, Russia

    L. V. Gening, A. N. Petrochenkov & V. Z. Tarantul

  2. Ophthalmologic Hospital, Moscow Municipal Board of Health, Moscow, 123001, Russia

    E. E. Grishina

Authors
  1. L. V. Gening
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  2. E. E. Grishina
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  3. A. N. Petrochenkov
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  4. V. Z. Tarantul
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Additional information

Original Russian Text © L.V. Gening, E.E. Grishina, A.N. Petrochenkov, V.Z. Tarantul, 2006, published in Genetika, 2006, Vol. 42, No. 1, pp. 98–103.

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Gening, L.V., Grishina, E.E., Petrochenkov, A.N. et al. Association between high activity of DNA polymerase iota and the development of human uveal melanoma. Russ J Genet 42, 84–88 (2006). https://doi.org/10.1134/S1022795406010121

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  • DOI: https://doi.org/10.1134/S1022795406010121

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