Abstract
The Drosophila melanogaster hdc gene controls trachea branching, which starts during embryo development. Expression in imaginal disks and reproductive organs suggests additional functions for the hdc gene. The gene was demonstrated to have a maternal effect, which was denied previously. Analysis of cell proliferation in imaginal disks with hdc mutations showed that the gene does not possess tumor suppressor properties at the levels of mosaic cuticle clones of adults and transplanted imaginal disks. Transplanted imaginal disks homozygous, but not heterozygous, for an hdc mutation were found to affect oogenesis in the recipient females, implicating the hdc activity in exchanging signals between different organs. Amino acid sequence analysis of the HDC protein revealed a region homologous to the human HRS proteins, which directly interact with the NF2 tumor suppressor on experimental evidence.
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References
Weaver, T., White R Headcase, An Imaginal Specific Gene Required for Adult Morphogenesis in Drosophila melanogaster, Development, 1995, vol. 121, pp. 4149–4160.
Steneberg, P., Englund, C., Kronhamn, J., et al., Translational Readthrough in the hdc mRNA Generates a Novel Branching Inhibitor in the Drosophila Trachea, Genes Dev., 1998, vol. 12, pp. 956–967.
Steneberg, P. and Samakovlis, C., A Novel Stop Codon Readthrough Mechanism Produces Functional Headcase Protein in Drosophila Trachea, EMBO Rep., 2001, vol. 21, no. 7, pp. 593–597.
Kozlova, A.V., Guryev, V.P., Blinov, A.G., and Omelyanchuk, L.V., The Headcase Gene: Proliferation or Hormonal Control?, Russ. J. Genet., 2002, vol. 36, no. 12, pp. 1395–1400.
Gatti, M. and Baker, B.S., Genes Controlling Essential Cell-Cycle Functions in Drosophila melanogaster, Genes Dev., 1989, vol. 3, pp. 438–453.
Omel’yanchuk, L.V. and Volkova, E.I., Expression Pattern of Cell Division Genes, Dokl. Akad. Nauk, 1996, vol. 347, no. 2, pp. 284–286.
Zeizer, E. and Chilo, B., Cell Fate Choices in Drosophila Tracheal Morphogenesis, BioEssays, 2000, vol. 22, no. 3, pp. 219–226.
The FlyBase Consortium, The FlyBase Database of the Drosophila Genome Projects and Community Literature, Nucleic Acids Res., 2000, vol. 31, pp. 172–175. http://flybase.org.
Chubykin, V.L. and Omel’yanchuk, L.V., Apoptosis in Developing and Adult D. melanogaster, Ontogenez, 1999, vol. 30, no. 6, pp. 417–424.
Sehnal, F. and Bryant, P.J., Delayed Pupariation in Drosophila Imaginal Disc Overgrowth Mutants Is Associated with Reduced Ecdysteroid Titer, J. Insect Physiol., 1993, vol. 39, no. 12, pp. 1051–1059.
Kawamura, K., Shibata, T., Saget, O., et al., A New Family of Growth Factors Produced by the Fat Body and Active on Drosophila Imaginal Discs, Development, 1999, vol. 128, pp. 211–219.
Scoles, D.R., Nguyen, V.D., Qin, Y., et al., Neurofibromatosis 2 (NF2) Tumor Suppressor Schwannomin and Its Interacting Protein HRS Regulate STAT Signaling, Hum. Mol. Genet., 2002, vol. 11, no. 25, pp. 3179–3189.
Sun, C., Haipek, C., Scoles, D.R., et al., Functional Analysis of the Relationship between the Neurofibromatosis 2 Tumor Suppressor and Its Binding Partner, Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate, Hum. Mol. Genet., 2002, vol. 11, no. 25, pp. 3167–3178.
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Original Russian Text © A.M. Gusachenko, E.M. Akhmamet’eva, L.V. Omel’yanchuk, 2006, published in Genetika, 2006, Vol. 42, No. 1, pp. 58–64.
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Gusachenko, A.M., Akhmamet’eva, E.M. & Omel’yanchuk, L.V. Range of potential functions of the Drosophila melanogaster hdc gene. Russ J Genet 42, 49–54 (2006). https://doi.org/10.1134/S1022795406010066
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DOI: https://doi.org/10.1134/S1022795406010066