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Furanocoumarins: History of Research, Diversity, Synthesis, Physiological Role in the Plant, and Medical Application

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Abstract

The review is devoted to furanocoumarins, a class of substances that are a combination of pyrone, benzene, and furan rings, possessing a system of conjugated double bonds (which in some cases can be disrupted). This group of compounds is currently being widely studied due to its phototoxic and medicinal properties. The work examines furanocoumarins of natural origin, identified in the family Umbelliferae, or Apiaceae, their diversity is structured; the history of their study, the currently known stages of their biosynthesis, and examples of their biological activity in plants, cell culture and for medical use are described.

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ACKNOWLEDGMENTS

I am grateful to Maria Dmitrievna Logacheva (Kharkevich Institute for Information Transmission Problems, Russian Academy of Sciences) for the initial idea of the work, Mikhail Georgievich Pimenov (Biological Faculty and Botanical Garden, Moscow State University) for consultations on the taxonomy of Umbelliferae, Polina Mavrina (VILAR) for assistance in digitizing full-text Soviet publications of the 1950s, and Nasaev Shamsutdin for preparing the figures.

Funding

The work was performed within the framework of the state research topic “The Study of Intra- and Intercellular Interactions by Molecular, Cell Biology, Physiology, and Mathematicals methods and Bioinformatics,” no. AAAA-A19–119121690043–3 (Belozersky Research Institute of Physical and Chemical Biology, Moscow State University).

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Abbreviations: 4CL—4-coumarate-coA ligase; 5-OH-XS—5-OH-xanthotoxin synthase AkPT1—prenyltransferase of Angelica keiskei; AS—angelicin synthase; BMT—bergaptol-O-methyltransferase; C2'H—p-coumaroyl-coA-2'hydroxylase; C4H—cinnamate C-4-hydroxylase; Cox-2—cyclooxygenase 2; CpPT1—prenyltransferase of Citrus paradisi; CS—columbianetin synthase; FDAFood and Drug Administration, United States; MS—marmesin synthase; NF-κB—Nuclear Factor Kappa of activated B cells; P5M—psoralen-5-monooxygenase; PAL—phenylalanine ammonia lyase; PI3/Akt—phosphatidylinositol 3-kinase; PS—psoralen synthase; P-UVA—psoralen-ultraviolet therapy; TNF—tumor necrosis factor; U6(8)DT (PT)—dimethylallyl diphosphate: umbelliferone prenyltransferase at position 6 or 8; XMT—xanthotoxol-O-methyltransferase; XS—xanthotoxol synthase; VILAR—All-Russia Institute of Medicinal and Aromatic Plants; BIN RAS—Komarov Botanical Institute, Russian Academy of Sciences.

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Shtratnikova, V.Y. Furanocoumarins: History of Research, Diversity, Synthesis, Physiological Role in the Plant, and Medical Application. Russ J Plant Physiol 70, 169 (2023). https://doi.org/10.1134/S1021443723700280

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