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Polyacrylic Acid: A Biocompatible and Biodegradable Polymer for Controlled Drug Delivery

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Abstract

Polyacrylic acid is a biocompatible and biodegradable polymer that has been widely investigated for use in drug delivery. It has a number of properties that make polyacrylic acid a promising material for various applications, including ability to form hydrogels, mucoadhesive properties, and stimuli-responsive behavior. Polyacrylic acid hydrogels can be used to deliver drugs to a variety of tissues and organs. They can be prepared in a variety of forms, including injectable gels, films, and tablets. These hydrogels can be loaded with a variety of drugs, including proteins, peptides, and small molecules. The mucoadhesive properties of polyacrylic acid make it a good choice for delivering drugs to the eye, nose, and skin. Polyacrylic acid can adhere to these mucosal surfaces, which can help to prolong the drug’s release and improve its bioavailability. The stimuli-responsive behavior of polyacrylic acid can be used to develop drug delivery systems that release drugs in response to specific stimuli, such as changes in pH, temperature, or ionic strength. This can be used to control the release of drugs in a way that is tailored to the specific needs of the patient. The research on the use of polyacrylic acid in drug delivery is ongoing. As our understanding of its properties and behavior improves, we can expect to see even more innovative and effective drug delivery systems developed in the future.

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Fig. 1.
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DATA AVAILABILITY

The analyzed data sets generated during the study are available from the corresponding author on reasonable request.

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This work was supported by ongoing institutional funding. No additional grants to carry out or direct this particular research were obtained.

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Authors and Affiliations

  1. Department of Biomedical Engineering, Meybod University, Meybod, Iran

    Hossein Eslami, Mojtaba Ansari, Ahmad Darvishi, Mahdieh Shami & Faezeh Kazemi

  2. Shiraz University of Medical Sciences, Shiraz, Iran

    Hossein Rayat Pisheh

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  1. Hossein Eslami
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Eslami, H., Ansari, M., Darvishi, A. et al. Polyacrylic Acid: A Biocompatible and Biodegradable Polymer for Controlled Drug Delivery. Polym. Sci. Ser. A 65, 702–713 (2023). https://doi.org/10.1134/S0965545X2460011X

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