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Hydrogels Based on Interpolymer Complexes of Sodium Alginate and Synthetic Polyacids

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Abstract

Effect of the structure of synthetic polyacids on the formation and properties of their interpolymer complexes with sodium alginate is investigated. The hydrogels was shown to be predominantly formed via hydrogen bonds, with their type depending on the structure of polyacid and the amount of bound water. Study of the behavior of the hydrogels in water and phosphate-buffed saline with рН 7.2 demonstrates that the properties of the hydrogels are influenced by the ratio of components and the treatment temperature, in addition to the nature of polyacid. The possibility of using hydrogels as a basis for drug delivery systems is examined by the example of preparation lidocaine.

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ACKNOWLEDGMENTS

We are grateful to I.M. Shelonina the employee of the OA Petrov Institute of Plastics for measuring and analysis of IR spectra.

Funding

This work was supported within the framework of State Assignment for the Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences.

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Authors and Affiliations

  1. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, 119991, Moscow, Russia

    I. F. Volkova, E. S. Grigoryan, G. A. Shandryuk & M. Yu. Gorshkova

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  1. I. F. Volkova
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  2. E. S. Grigoryan
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  3. G. A. Shandryuk
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  4. M. Yu. Gorshkova
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Correspondence to M. Yu. Gorshkova.

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Translated by Soboleva

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Volkova, I.F., Grigoryan, E.S., Shandryuk, G.A. et al. Hydrogels Based on Interpolymer Complexes of Sodium Alginate and Synthetic Polyacids. Polym. Sci. Ser. A 65, 85–95 (2023). https://doi.org/10.1134/S0965545X23700803

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  • DOI: https://doi.org/10.1134/S0965545X23700803

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