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Multilayered Particles Based on Biopolyelectrolytes as Potential Peptide Delivery Systems

Polymer Science, Series A volume 62, pages 43–53 (2020)Cite this article

Abstract

A series of amphiphilic charged copolymers of amino acids is synthesized, and their binding to cationic and anionic peptides is studied. The resulting interpolyelectrolyte complexes are additionally stabilized by cationic/anionic polysaccharides using surface layering. The positive effect of coatings on the release rate of peptides and decrease in the cytotoxicity and increase in the stability of the resulting peptide delivery systems in biological media is shown.

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Funding

This study was supported by the Russian Science Foundation (project no. 19-73-20157).

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Authors and Affiliations

  1. Institute of Macromolecular Compounds, Russian Academy of Sciences, 199004, St. Petersburg, Russia

    N. N. Zashikhina, I. I. Tarasenko & E. G. Korzhikova-Vlakh

  2. St. Petersburg State University, Institute of Chemistry, 198504, Peterhof, St. Petersburg, Russia

    D. V. Yudin, O. M. Osipova & E. G. Korzhikova-Vlakh

Authors
  1. N. N. Zashikhina
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  2. D. V. Yudin
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  3. I. I. Tarasenko
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  4. O. M. Osipova
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  5. E. G. Korzhikova-Vlakh
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Correspondence to E. G. Korzhikova-Vlakh.

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Zashikhina, N.N., Yudin, D.V., Tarasenko, I.I. et al. Multilayered Particles Based on Biopolyelectrolytes as Potential Peptide Delivery Systems. Polym. Sci. Ser. A 62, 43–53 (2020). https://doi.org/10.1134/S0965545X20010125

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  • DOI: https://doi.org/10.1134/S0965545X20010125