Abstract
Effect of the nature of a counterion in the salt forms of cellulose sulfate acetate on the composition, hydrodynamic characteristics, surface activity, and sizes of supramolecular structures of water-soluble complexes with ceftriaxone and cefotaxime is studied. The relationship between the position of counterion in the lyotropic series of alkali-metal cations and the properties of complexes is ascertained. It is shown that the amount of the bound antibiotic decreases in the sequence K+–Na+–Li+. The sizes of micellar-like supramolecular structures in solution and in the solid phase (films cast from solution) change in a similar manner. These structures can form because of hydrophobization of the macromolecular chain of polyelectrolyte. It is found that the adsorption of ceftriaxone and cefotaxime polymer complexes on various carbon sorbents depends on the porous structure of the activated carbon and makes it possible to provide the transfer of antibiotic to the small intestine in the unchanged form. This opens the possibility to create a new tablet dosage form of cephalosporin antibiotics while fully preserving their pharmacological activity.
Similar content being viewed by others
REFERENCES
L. Balant, P. Dayer, and R. Auckenthaler, Clin. Pharmacokinet. 10, 101 (1985).
D. L. DeBrouse, US Patent No. 11938638 (2007).
S. Choi and J. Lee, US Patent No. 6248360 (2000).
N. Patel, D. Lalwani, S. Gollmer, E. Injeti, Y. Sari, and J. Nessamony, Prog. Biomater. 5, 117 (2016).
E. A. Shakhno, T. A. Savitskaya, and D. D. Grinshpan, T. G. Pokrovskaya, V. I. Yakushev, and M. V. Pokrovskii, Pharm. Chem. J. 51, 970 (2018).
D. D. Grinshpan, T. A. Savitskaya, N. G. Tsygankova, S. E. Makarevich, S. M. Tretsiakova, and T. N. Nevar, Int. J. Polym. Sci. 2010, Article ID 831658 (2010).
L. A. Kostromina, V. N. Skumok, and N. A. Skorik, Chemistry of Coordination Compounds (Khimiya, Moscow, 1990) [in Russian].
N. I. Avvakumova, N. A. Budarina, S. M. Divgun, A. E. Zaikin, E. V. Kuznetsov, and V. F. Kurenkov, Tutorial on Chemistry and Physics of Polymers, Ed. by V. F. Kurenkova (Khimiya, Moscow, 1990) [in Russian].
H. Fabre, N. H. Eddine, and M. D. Berge, J. Pharm. Sci. 74, 85 (1985).
V. G. Alekseev, N. V. Vorob’ev, and Yu. Ya. Yakubovich, Russ. J. Phys. Chem 80, 1615 (2006).
V. A. Kabanov and A. B. Zezin, Russ. Chem. Rev. 52, 833 (1982).
T. A. Savitskaya, E. A. Shakhno, E. S. Firago, D. D. Grinshpan, and O. A. Ivashkevich, Dokl. NAN Belarusi 61 (3), 58 (2017).
M. K. Krotova, V. V. Vasilevskaya, L. Leclercq, M. Boustta, M. Vert, and A. R. Khokhlov, Macromolecules 42, 7495 (2009).
V. G. Nefedov, A. G. Atapin, and D. A. Golovko, Vost.-Evr. Zh. Peredovykh Tekhnol. 78 (6), 17 (2017).
E. V. Butyrskaya, V. A. Shaposhnik, and A. M. Butyrskii, Vestn. VGU. Ser.: Khim. Biol. Farmtsiya 2, 25 (2004).
Y. Zhang, J. F. Douglas, B. D. Ermi, and E. J. Amis, J. Chem. Phys. 114, 3299 (2001).
T. A. Savitskaya, T. N. Nevar, N. G. Tsygankova, M. G. Krivova, I. V. Reznikov, E. A. Shakhno, A. I. Vezentsev, and D. D. Grinshpan, Sviridovskie Chteniya: Sb. St, No. 10, 132 (2015).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated by T. Soboleva
Rights and permissions
About this article
Cite this article
Savitskaya, T.A., Shakhno, E.A., Grinshpan, D.D. et al. Soluble Polymer Complexes of Ceftriaxone and Cefotaxime with Cellulose Sulfate Acetate Salt Forms and Their Adsorption on Carbon Sorbents. Polym. Sci. Ser. A 61, 274–286 (2019). https://doi.org/10.1134/S0965545X1903012X
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S0965545X1903012X