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Formulation of Pioglitazone-Eudragit® RS100 Nanobeads and Nanofibers Using Electrospraying Technique

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Abstract

In the present study, a novel polymeric nanoparticle-based drug delivery system was developed to enhance the dissolution rate of poorly water-soluble drug pioglitazone hydrochloride (PGH) using hydrophilic Eudragit® RS100 (Eudr) as a carrier. The new nanoformulations were prepared in different drug : polymer ratios (1 : 5 and 1 : 10) at total solution concentrations of (5–20% w/v) employing electrospraying as one-step, self-dispersing, and productive method. The physicochemical attributes of the electrosprayed samples (ESs) were evaluated conducting scanning electron microscopy (FE-SEM), differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), Fourier transform infrared spectroscopy (FTIR) as well as in vitro dissolution studies. FE-SEM results indicated that the size and morphology of the ESs were influenced by the drug: polymer ratios and solution concentrations, where a rise in the polymer ratio led to the particle size augmentation while the solution concentration enhancement yielded in the fiber establishment. The DSC and XRPD analysis revealed amorphization of the drug where, the FTIR evaluation verified absence of any chemical interactions between the drug-polymer within the electrospraying procedure. In vitro release studies of the ESs exhibited biphasic release pattern with higher release rates compared to the pure drug. Our finding demonstrated that the electrospraying as a cost-benefit technique could be effectively employed to improve the physicochemical features of PGH.

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ACKNOWLEDGMENTS

This study was financially supported by the Vice Chancellor for Research of Tabriz University of Medical Sciences, Tabriz, Iran.

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Authors and Affiliations

  1. Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran

    Khosro Adibkia & Karim Osouli-Bostanabad

  2. Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran

    Khosro Adibkia, Mohammad Barzegar-Jalali, Niloofar Balaei, Karim Osouli-Bostanabad, Solmaz Ghajar & Shahram Emami

  3. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Mohammad Barzegar-Jalali, Niloofar Balaei, Solmaz Ghajar & Solmaz Zakhireh

  4. Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Golgasht St., Daneshgah Ave., Tabriz, Iran

    Mohammad Barzegar-Jalali

  5. Students Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran

    Niloofar Balaei, Karim Osouli-Bostanabad & Solmaz Ghajar

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  1. Khosro Adibkia
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Correspondence to Mohammad Barzegar-Jalali.

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Khosro Adibkia, Barzegar-Jalali, M., Balaei, N. et al. Formulation of Pioglitazone-Eudragit® RS100 Nanobeads and Nanofibers Using Electrospraying Technique. Polym. Sci. Ser. A 61, 407–416 (2019). https://doi.org/10.1134/S0965545X19030015

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