Abstract
Hydrogels with an increased content of fine pores are synthesized via the copolymerization of acrylamide with N-(2-D-glucose) acrylamide and N,N-methylenebis(acrylamide) in the presence of concanavalin A and mercaptoacetic acid. Insulin introduced into the hydrogels is spontaneously released in response to increase in the concentration of glucose in the environment via a two-step mechanism similar to that in the case of the pancreas and the maximum rate is observed at the first stage.
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References
M. Saffran, in Targeting of Drugs: The Challenge of Peptides and Proteins, Ed. by G. Gregoriadis (Plenum Press, New York, 1992), p. 89.
R. K. Murray, D. K. Granner, P. A. Mayes, and V. W. Rodwell, Harper’s Biochemistry (Appleton & Lange, Norwalk; San Mateo, 1984).
J. Kost, T. A. Horbett, B. D. Ratner, and M. Singh, J. Biomed. Mater. Res. 19 (9), 1117 (1985).
L. R. Brown, E. R. Edelman, F. Fischel-Ghodsian, and R. Langer, J. Pharm. Sci. 85 (12), 1341 (1996).
T. Traitel, Y. Cohen, and J. Kost, Biomaterials 21 (16), 1679 (2000).
L. Y. Chu, Y. Li, J. H. Zhu, H. D. Wang, and Y. J. Liang, J. Controlled Release 97 (1), 43 (2004).
X. Chen, W. Wu, Z. Guo, J. Xin, and J. Li, Biomaterials 32 (6), 1759 (2011).
S. Kitano, K. Kataoka, Y. Koyama, T. Okano, and Y. Sakurai, Makromol. Chem., Rapid Commun. 12 (2), 227 (1992).
Y. Wang, X. Zhang, Y. Han, C. Cheng, and C. Li, Carbohydr. Res. 89 (1), 124 (2012).
Y. Yao, L. Zhao, J. Yang, and J. Yang, Biomacromolecules 13 (6), 1837 (2012).
Q. Guo, T. Zhang, J. An, Z. Wu, Y. Zhao, X. Dai, X. Zhang, and C. Li, Biomacromolecules 16 (10), 3345 (2015).
Z. Chai, L. Ma, Y. Wang, and X. Ren, J. Biomater. Sci., Polym. Ed. 27 (7), 599 (2016).
K. Makino, E. J. Mack, T. Okano, and S. W. Kim, J. Controlled Release 12 (6), 235 (1990).
A. A. Obaidat and K. Park, Biomaterials 18 (11), 801 (1997).
J. J. Kim and K. Park, J. Controlled Release 77 (1–2), 39 (2001).
I. L. Valuev, V. V. Chupov, G. A. Sytov, L. I. Valuev, and N. A. Plate, Vysokomol. Soedin., Ser. B 39 (4), 751 (1997).
I. L. Valuev, L. V. Vanchugova, and L. I. Valuev, Polym. Sci., Ser. A 53 (5), 385 (2011).
Y. Ivakura, Y. Imai, and Y. Vagu, J. Polym. Sci., Part A-1: Polym. Chem. 6 (6), 1625 (1968).
L. V. Vanchugova, L. I. Valuev, I. L. Valuev, and Yu. Talyzenkov, Polym. Sci., Ser. B 55 (1–2), 77 (2013).
L. I. Valuev, I. L. Valuev, L. V. Vanchugova, and I. V. Obydennova, Polym. Sci., Ser. B 57 (5), 456 (2015).
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Original Russian Text © L.I. Valuev, I.L. Valuev, L.V. Vanchugova, I.V. Obydennova, 2018, published in Vysokomolekulyarnye Soedineniya, Seriya A, 2018, Vol. 60, No. 4, pp. 308–311.
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Valuev, L.I., Valuev, I.L., Vanchugova, L.V. et al. Glucose-Sensitive Hydrogels for the Controlled Release of Insulin. Polym. Sci. Ser. A 60, 495–498 (2018). https://doi.org/10.1134/S0965545X18040132
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DOI: https://doi.org/10.1134/S0965545X18040132