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Preparation of Magnetic Zeolites for Medicinal Purposes

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Abstract

Magnetic Beta zeolite was synthesized under hydrothermal conditions by doping aluminosilicate gel with magnetite nanoparticles. The strength of Fe3O4 nanoparticle fixation in the composite synthesized under hydrothermal conditions was evaluated in comparison with the samples prepared by coprecipitation. The efficiency of the adsorption and desorption of 5-fluorouracil antitumor drug on samples of Beta zeolite and Beta–Fe3O4 magnetic nanocomposite was studied. The kinetics of the 5-fluorouracil release from the composite was described using the Higuchi model. The physicochemical properties of the samples were characterized. The hemolytic activity of the initial Beta zeolite and magnetic composite based on it toward human blood cells and the ability for biodegradation in a synthetic biological medium were studied with the aim of ensuring safe use of the materials as drug carriers. The results of the study allow conclusions on the possibility of using the magnetic nanocomposites in vivo.

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Funding

The study was performed within the framework of the government assignment for the Grebenshchikov Institute of Silicate Chemistry, Russian Academy of Sciences (theme no. 0081-2022-0001).

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  1. Grebenshchikov Institute of Silicate Chemistry, 199034, St. Petersburg, Russia

    E. Yu. Brazovskaya & O. Yu. Golubeva

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  1. E. Yu. Brazovskaya
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Brazovskaya, E.Y., Golubeva, O.Y. Preparation of Magnetic Zeolites for Medicinal Purposes. Pet. Chem. 63, 820–828 (2023). https://doi.org/10.1134/S0965544123050055

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