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Gas Permeation and Hemocompatibility of Novel Perfluorinated Polymers for Blood Oxygenation

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Abstract

Gas permeation properties of three highly permeable perfluorinated polymers (polyhexafluoropropylene (PHFP), amorphous Teflon AF2400, and polyperfluoro(2-methyl-2-ethyl-dioxole-1,3) (PPFMED)), which are promising materials for the dense thin layer of hollow fiber membranes for extracorporeal membrane oxygenation have been studied using nitrogen, oxygen, and carbon dioxide. Hemocompatibility of the polymeric films has also been investigated on whole blood from healthy donors. Gas permeation of the polymers increases in the order PHFP < PPFMEDD < AF2400, with PHFP alone having the permeability coefficients of the gases do not below those of polydimethylsiloxane applied as the selective layer of blood oxygenation membranes. Hemocompatibility of the polymers declines in the order PHFP > PPFMED > AF2400, with the most permeable polymer AF2400 exhibiting the worst hemocompatibility among the other polymers studied. Polyperfluoro(2-methyl-2-ethyl-dioxole-1,3) is shown to be the most appropriate polymer to fabricate hollow fiber membranes for blood oxygenation.

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ACKNOWLEDGMENTS

This work was performed within the framework of the state task of the Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences.

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Authors and Affiliations

  1. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, 119991, Moscow, Russia

    A. Yu. Alentiev, N. A. Belov & R. Yu. Nikiforov

  2. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991, Moscow, Russia

    E. V. Polunin

  3. Sklifosovskii Research Institute of Emergency Care, 129090, Moscow, Russia

    N. V. Borovkova, A. K. Evseev, M. S. Makarov, I. V. Goroncharovskaya, M. V Storozheva & V. S. Zhuravel

Authors
  1. A. Yu. Alentiev
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  2. N. A. Belov
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  3. R. Yu. Nikiforov
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  4. E. V. Polunin
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  5. N. V. Borovkova
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  6. A. K. Evseev
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  7. M. S. Makarov
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  8. I. V. Goroncharovskaya
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  9. M. V Storozheva
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  10. V. S. Zhuravel
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Corresponding author

Correspondence to A. Yu. Alentiev.

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Translated by E. Boltukhina

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Alentiev, A.Y., Belov, N.A., Nikiforov, R.Y. et al. Gas Permeation and Hemocompatibility of Novel Perfluorinated Polymers for Blood Oxygenation. Pet. Chem. 58, 740–746 (2018). https://doi.org/10.1134/S0965544118090025

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  • DOI: https://doi.org/10.1134/S0965544118090025

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