Abstract
The results obtained in recent years on the numerous functions of the MYC protein convincingly indicate that MYC overexpression induced by physical activity (PA) occurs at the transcriptional and epigenetic levels with the participation of low molecular weight metabolites formed during the enhancement of intermediate metabolism. The current hypothesis proposes that the MYC network of transcription factors may account substantially for the exercise-induced adaptive changes in muscle and other vital organs through changes in lactate dynamics. This review presents the MYC transcription factor network that is involved in cell cycle regulation, growth, proliferation, and cell metabolism.
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I.V. Astratenkova, V.A. Rogozkin—collection and analysis of literary sources, N.D. Golberg—editing and technical design of the manuscript.
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Astratenkova, I.V., Golberg, N.D. & Rogozkin, V.A. Regulation of Gene Expression by the MYC Transcription Factor Network During Exercise. Hum Physiol 49, 444–452 (2023). https://doi.org/10.1134/S036211972360011X
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DOI: https://doi.org/10.1134/S036211972360011X