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Relationships between the Levels of Dopamine, Thyroid, and Antispermal Antibodies in Populations of the European and Asian North

  • EXPERIMENTAL AND GENERAL THEORETICAL STUDIES
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Abstract

Autoantibodies to thyroglobulin (AntiTGs) and thyroperoxydase (AntiTPOs) define in many ways thyroid activity, whereas antispermal antibodies (ASABs) control the reproductive system. Most of these antibodies belong to immunoglobulin class G; dopamine can control the processes of antibody production. We have conducted our study to identify differences in the content and ratio of dopamine, thyroid autoantibodies and ASABs, and thyroglobulin (TG) in residents of the European and Asian North, taking into account gender. We have tested 336 practically healthy males and females at the ages from 22 to 44 and 45 to 59 years. Blood serum was analyzed for autoantibodies and plasma for dopamine. A higher frequency of excess concentrations of dopamine in men and undetectable concentrations of dopamine in women was shown. A higher level of dopamine in the inhabitants of the Asian North was combined with a lower level of AntiTGs with an increase in TG and ASABs, which may indicate an inhibitory effect of dopamine on the synthesis of AntiTGs, leading to an increase in thyroid activity. In women with higher concentrations of antithyroid antibodies and lower levels of TG, their deviations from the norm were more often recorded, which may be associated with a higher frequency of undetectable levels of dopamine, leading to the absence of an inhibitory effect of dopamine on the content of autoantibodies in some examined individuals, which contributes to an increase in autoimmunization. A unidirectional increase in dopamine and ASABs was shown in representatives of the Asian North relative to the European population with a negative correlation between them, which, in addition to their synergistic effect on spermatozoa, may also indicate an inhibitory effect of dopamine on the content of ASABs. Features of the influence of blood dopamine on the autoimmune response can be the basis for preventing the risk of autoimmune pathology in residents of various territories of the North, which are characterized by extreme climate.

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Funding

The study was carried out in accordance with the state task of the Federal Center for Integrated Arctic Research, Ural Branch, Russian Academy of Sciences (state registration number 122011800392-3).

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Authors and Affiliations

  1. Federal Center for Integrated Arctic Research, Ural Branch, Russian Academy of Sciences, Archangelsk, Russia

    E. V. Tipisova, V. A. Alikina, I. N. Molodovskaya, A. E. Elfimova & V. N. Zyabisheva

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  1. E. V. Tipisova
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  2. V. A. Alikina
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  3. I. N. Molodovskaya
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  4. A. E. Elfimova
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  5. V. N. Zyabisheva
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Correspondence to E. V. Tipisova.

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ETHICS APPROVAL AND CONSENT TO PARTICIPATE

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. They were also approved by the Commission on Biomedical Ethics of the Institute of Physiology of Natural Adaptations (protocol no. 2 dated November 4, 2016).

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The authors of this work declare that they have no conflicts of interest.

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Translated by A. Deryabina

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Tipisova, E.V., Alikina, V.A., Molodovskaya, I.N. et al. Relationships between the Levels of Dopamine, Thyroid, and Antispermal Antibodies in Populations of the European and Asian North. Hum Physiol 49, 830–836 (2023). https://doi.org/10.1134/S0362119723070162

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