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The Role of Asprosin in the Regulation and Mechanisms of Oxygen Transport in the Blood and the Gas Transmitter System in Men with Different Body Mass Index

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Abstract

The purpose of this study is to evaluate the role of asprosin in the regulation and mechanisms of oxygen transport in the blood and the gas transmitter system in men with different body mass index. The indicators of lipid and carbohydrate metabolism, as well as the oxygen transport function of the blood and the concentration of gas transmitters, nitrogen monoxide and hydrogen sulfide in it, were determined. A higher concentration of asprosin was found in individuals with an increased body mass index and grade I obesity. With an increased content of asprosin, there is a decrease in the main indicators of blood oxygenation and an increase in the affinity of hemoglobin for oxygen. An increase in the concentration of nitrogen monoxide and a decrease in hydrogen sulfide were revealed at a high content of asprosin, which may be important for the formation of the mechanisms of oxygen transport in the blood.

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Funding

The study was carried out at the expense of the General Directorate of Sciences of the Belarusian State University (project no. 20 210 366).

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Authors and Affiliations

  1. Grodno State Medical University, Grodno, Belarus

    V. V. Zinchuk & N. V. Glutkina

  2. Yanka Kupala State University of Grodno, Grodno, Belarus

    Al-Jebur Jaafar Shati Owaid

Authors
  1. V. V. Zinchuk
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  2. Al-Jebur Jaafar Shati Owaid
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  3. N. V. Glutkina
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Corresponding author

Correspondence to V. V. Zinchuk.

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COMPLIANCE WITH ETHICAL STANDARDS

All studies were conducted in accordance with the principles of biomedical ethics formulated in the Declaration of Helsinki 1964 and its subsequent updates and approved by the regional bioethical committee of the Grodno State University named after Yanka Kupala (Grodno).

CONFLICT OF INTEREST

The authors declare the absence of an obvious and potential conflict of interest related to the publication of this article.

INFORMED CONSENT

Each participant in the study provided a voluntary written informed consent signed by him after explaining to him the potential risks and benefits, as well as the nature of the upcoming study.

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Zinchuk, V.V., Owaid, AJ.J. & Glutkina, N.V. The Role of Asprosin in the Regulation and Mechanisms of Oxygen Transport in the Blood and the Gas Transmitter System in Men with Different Body Mass Index. Hum Physiol 49, 421–427 (2023). https://doi.org/10.1134/S0362119722700189

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  • DOI: https://doi.org/10.1134/S0362119722700189

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