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Measurement of Parameters Characterizing Early Vascular Aging with the Use of an Oscillometric Method during Spaceflight

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Abstract

The article is devoted to the study of the state of the vascular wall based on the data on pulse wave velocity used as a vascular biomarker to predict and prevent early vascular aging. The studies were carried out on Russian cosmonauts who performed 6-month space flights using a Mobilograph device, which passed all the necessary tests, was certified for operation on board the International Space Station and allows evaluating the parameters of central hemodynamics. The experiment was carried out twice before the flight, every month during the flight, and also on days +4 and +8 after landing. Pulse wave velocity in all measurements was not shown to exceed the threshold values, thus suggesting the absence of vascular risk and the risk of cardiovascular pathologies in astronauts working in low-Earth orbit. However, this conclusion may be limited by the features of the method and the device used.

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Funding

The studies were carried out within the framework of the basic topic of the Russian Academy of Sciences no. 64.1 for 2013–2023. Analysis of pre- and postflight data was performed under international contracts nos. 16-23-07 (March 29, 2016–December 31, 2018) and 07-35 (September 7, 2018–December 31, 2020).

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Authors and Affiliations

  1. Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia

    E. S. Luchitskaya, I. I. Funtova & V. B. Rusanov

  2. German Aerospace Center, Cologne, Germany

    J. Tank, S. Moestl, F. Hoffmann & J. Hönemann

  3. Cologne University Clinic, Cologne, Germany

    H. Reuter, F. Hoffmann & J. Hönemann

Authors
  1. E. S. Luchitskaya
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  2. I. I. Funtova
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  3. J. Tank
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  4. H. Reuter
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  5. S. Moestl
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  6. F. Hoffmann
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  7. J. Hönemann
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  8. V. B. Rusanov
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Corresponding author

Correspondence to E. S. Luchitskaya.

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COMPLIANCE WITH ETHICAL STANDARDS

All procedures performed in studies involving human participants were in accordance with the biomedical ethics principles formulated in the 1964 Helsinki Declaration and its later amendments and approved by the local Bioethics Committee of the Institute of Biomedical Problems, Russian Academy of Sciences (Moscow).

CONFLICT OF INTERESTS

The authors declare that they do not have a conflict of interest.

INFORMED CONSENT

Each study participant provided a voluntary written informed consent signed by him after explaining to him the potential risks and benefits, as well as the nature of the upcoming study.

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Translated by E. Babchenko

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Luchitskaya, E.S., Funtova, I.I., Tank, J. et al. Measurement of Parameters Characterizing Early Vascular Aging with the Use of an Oscillometric Method during Spaceflight. Hum Physiol 48, 851–855 (2022). https://doi.org/10.1134/S036211972207012X

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  • DOI: https://doi.org/10.1134/S036211972207012X

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