Skip to main content
SpringerLink
Log in

Influence of Age on Baroreflex Synchronization of Blood Pressure and Heart Rate during the Passive Tilt Test

  • REVIEWS
  • Published:
Human Physiology Aims and scope Submit manuscript

Abstract

Age-related changes in phase synchronization of spontaneous mean arterial pressure (MAP) and heart rate (HR) fluctuations within the baroreflex wave range (around 0.1 Hz) were studied in 66 subjects aged 20 to 52 years. During the head-up tilt test, MAP (photocompensation method), ECG (to calculate heart rate), and respiratory rate were continuously recorded. To quantify MAP–HR coupling, the phase synchronization index (PSI) was used. In people over 40 years, an increase in phase synchronization of MAP and HR was found in a supine position compared with subjects aged 20–24 years. At the same time, the increase in PSI of MAP and HR in response to orthostatic stress decreased after the age of 40, which may reflect a decrease in baroreflex activity with age.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Fig. 2.

Similar content being viewed by others

REFERENCES

  1. Smit, A.A.J., Timmers, H.J.L.M., Wieling, W.W., et al., Long-term effects of carotid sinus denervation on arterial blood pressure in humans, Circulation, 2002, vol. 105, no. 11, p. 1329.

    Article  Google Scholar 

  2. Convertino, V.A., Neurohumoral mechanisms associated with orthostasis: reaffirmation of the significant contribution of the heart rate response, Front. Physiol., 2014, vol. 5, p. 1.

    Article  Google Scholar 

  3. Mol, A.R., Reijnierse, E.M., Bui Hoang, P.T.S., et al., Orthostatic hypotension and physical functioning in older adults: a systematic review and meta-analysis, Ageing Res. Rev., 2018, vol. 48, p. 122.

    Article  Google Scholar 

  4. Parati, G., Frattola, A., Rienzo, M.Di., et al., Effects of aging on 24-h dynamic baroreceptor of heart rate in ambulant subjects, Am. J. Physiol., 1995, vol. 268, p. H1606.

    CAS  Google Scholar 

  5. Smyth, H.S., Sleight, P., and Pickering, G.W., Reflex regulation of arterial pressure during sleep in man: a quantitative method of assessing baroreflex sensitivity, Circ. Res., 1969, vol. 24, p. 109.

    Article  CAS  Google Scholar 

  6. Jones, P.P., Christou, D.D., Jordan, J., and Seals, D.R., Baroreflex buffering is reduced with age in healthy men, Circulation, 2003, vol. 107, no. 13, p. 1770.

    Article  Google Scholar 

  7. Rudas, L., Crossman, A.A., Morillo, C.A., et al., Human sympathetic and vagal baroreflex responses to sequential nitroprusside and phenylephrine, Am. J. Ph-ysiol.: Heart Circ. Physiol., 1999, vol. 276, no. 5, p. H1691.

    CAS  Google Scholar 

  8. Laitinen, T., Hartikainen, J., Vanninen, E., et al., Age and gender dependency of baroreflex sensitivity in healthy subjects, J. Appl. Physiol., 1998, vol. 84, no. 2, p. 576.

    Article  CAS  Google Scholar 

  9. Monahan, K.D., Dinenno, F.A., Tanaka, H., et al., Regular aerobic exercise modulates age-associated declines in cardiovagal baroreflex sensitivity in healthy men, J. Physiol., 2000, vol. 529, no. 1, p. 263.

    Article  CAS  Google Scholar 

  10. Wieling, W., Heart rate variability in healthy subjects: effect of age and derivation of normal ranges for tests of autonomic function, Br. Heart J., 1987, vol. 57, no. 1, p. 109.

    Article  CAS  Google Scholar 

  11. Schwartz, J.B., Gibb, W.J., and Tran, T., Aging effects on heart rate variation, J. Gerontol., 1991, vol. 46, no. 3, p. 99.

    Article  Google Scholar 

  12. Shvalev, V.N. and Tarskiy, N.A., The phenomenon of early age-related involution of the sympathetic division of the autonomic nervous system, Kardiologiya, 2001, no. 2, p. 10.

  13. Tank, J., Baevski, R.M., Fender, A., et al., Reference values of indices of spontaneous baroreceptor reflex sensitivity, Am. J. Hypertens., 2000, vol. 13, no. 3, p. 268.

    Article  CAS  Google Scholar 

  14. Borovik, A.S., Kuznetsov, S.Y., and Vinogrado-va, O.L., Phase synchronization of arterial pressure and heart rate as a measure of baroreflex activity, Conference of the European Study Group on Cardiovascular Oscillations (ESGCO), 2014, p. 217. https://doi.org/10.1109/ESGCO.2014.6847597

    Book  Google Scholar 

  15. Borovik, A.S., Orlova, E.A., Tomilovskaya, E.S., et al., Phase coupling between baroreflex oscillations of blood pressure and heart rate changes in 21-day dry immersion, Front. Physiol., 2020, vol. 11, p. 1.

    Article  Google Scholar 

  16. Negulyaev, V.O., Tarasova, O.S., Tarasova, N.V., et al., Phase synchronization of baroreflex oscillations of blood pressure and pulse interval in rats: the effects of cardiac autonomic blockade and gradual blood loss, Physiol. Meas., 2019, vol. 40, no. 5, p. 1.

    Article  Google Scholar 

  17. Shvalev, V.N., Sosunov, A.A., and Guski, G., Morfologicheskie osnovy innervatsii serdtsa (Morphological Bases of the Heart Innervation), Moscow, 1992.

    Google Scholar 

  18. James, M.A. and Potter, J.F., Orthostatic blood pressure changes and arterial baroreflex sensitivity in elderly subjects, Age Ageing, 1999, vol. 28, no. 6, p. 522.

    Article  CAS  Google Scholar 

  19. Shi, X., Wray, D.W., Formes, K.J., et al., Orthostatic hypotension in aging humans, Am. J. Physiol.: Heart Circ. Physiol., 2000, vol. 279, no. 4 (48-4), p. 1548.

  20. Wray, D.W., Formes, K.J., Weiss, M.S., et al., Vagal cardiac function and arterial blood pressure stability, Am. J. Physiol.: Heart Circ. Physiol., 2001, vol. 281, no. 5 (50-5), p. 1870.

Download references

Funding

The study was carried out according to the Program of Fundamental Scientific Research (topic 64.1) and supported by the Russian Foundation for Basic Research, project no. 20-015-00536.

Author information

Authors and Affiliations

  1. Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia

    E. A. Orlova, O. S. Tarasova & A. S. Borovik

  2. Moscow State University, Moscow, Russia

    O. S. Tarasova

  3. Institute of Developmental Physiology, Russian Academy of Education, Moscow, Russia

    V. D. Son’kin

Authors
  1. E. A. Orlova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. O. S. Tarasova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. V. D. Son’kin
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. S. Borovik
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. S. Borovik.

Ethics declarations

Conflict of interest. The authors declare that they do not have a conflict of interest.

Informed consent. Each study participant provided a voluntary written informed consent signed by him after explaining to him the potential risks and benefits, as well as the nature of the upcoming study.

Additional information

Translated by E. Babchenko

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Orlova, E.A., Tarasova, O.S., Son’kin, V.D. et al. Influence of Age on Baroreflex Synchronization of Blood Pressure and Heart Rate during the Passive Tilt Test. Hum Physiol 48, 822–826 (2022). https://doi.org/10.1134/S0362119722070088

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0362119722070088

Keywords:

Search

Navigation