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Cerebral Disorders and Consequences of Delayed Intrauterine Development of a Full-Term Baby: The Role of Oxidative Stress and Melatonin

Human Physiology volume 48, pages 340–345 (2022)Cite this article

Abstract

The review presents the results of clinical and experimental studies, indicating a high frequency of structural and functional disorders, brain development, and mechanisms that determine long-term adverse effects in children born with intrauterine growth retardation (IUGR). The key role of maternal melatonin and its circadian rhythm in protection against damage caused by oxidative stress and inflammation during pregnancy complications is considered. The development of specific biomarkers for early diagnosis of brain damage in IUGR of a child and methods of early neuroprotection will make it possible to approach the prevention of neuropsychiatric consequences from a new perspective.

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  1. Ott Research Institute of Obstetrics, Gynecology, and Reproductology, St. Petersburg, Russia

    I. I. Evsyukova

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Evsyukova, I.I. Cerebral Disorders and Consequences of Delayed Intrauterine Development of a Full-Term Baby: The Role of Oxidative Stress and Melatonin. Hum Physiol 48, 340–345 (2022). https://doi.org/10.1134/S0362119722030057

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Keywords:

  • newborns
  • IUGR
  • brain
  • neuropsychiatric consequences
  • mechanism
  • melatonin