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Comparison of the Serum Concentrations of Several Cytokines and the Brain Distribution of a Direct Current Potential Level in Patients with Vibration Disease

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Abstract

The development of vibration disease (VD) is based on the stagnant excitation response that arises mainly in the sympathetic part of the autonomic nervous system, the hypothalamic region, and cortical areas of the brain and leads imbalanced endocrine regulation and metabolic insufficiency. VD is due to a combined effect of local and general vibration and is thought to be a membrane-associated pathological process, membranes of the vascular endothelium being the most vulnerable. It is therefore of importance to study the relationship between topography of direct current (DC) potentials, which integrally reflect the membrane potentials of neurons, glia, and the blood–brain barrier, and serum concentrations of pro- and anti-inflammatory cytokines. The aim of the study was to compare the changes in serum cytokine concentrations and the brain DC potential distribution in patients with VD due to local and general vibrations. The study involved 28 patients who were diagnosed with stage II VD due to occupational exposure to vibration, lacked exposure to vibration at the time of the study, and had no comorbid pathology that could affect cytokine metabolism. A control group included 15 men without occupational exposure to vibration. The serum concentrations of IL-2, IL-4, IL-8, and IFN-γ were determined by the enzyme-linked immunosorbent assay (ELISA). The DC-potential level was recorded using neuro-energy mapping. Statistical analyses included the Shapiro–Wilk W-test, Mann–Whitney U-test, and Spearman’s rank correlation. The VD patients compared with the controls showed a moderately elevated DC-potential level in the central (p = 0.04), left central (p = 0.02), and right temporal (p = 0.03) leads. The IL-2 concentration was found to correlate with the DC potential in the left central (rs = 0.47), right parietal (rs = 0.37), and occipital (rs = 0.38) regions of the brain. The IL-4 concentration correlated with the DC potential in the right (rs = 0.41) and left (rs = 0.45) frontal regions and the temporal (rs = 0.39) and central (rs = 0.51) interhemispheric gradients. The IL-8 concentration correlated with the DC potential in the right (rs = 0.41) and left (rs = 0.43) frontal regions and the central (rs = 0.38) interhemispheric gradient. IFN-γ correlated with the DC potential of the left frontal (rs = 0.41) region and the central (rs = 0.42) interhemispheric gradient. An increase in DC potential in the frontal (right and left), right temporal, occipital, central, and right parietal regions of the brain was associated with IL-8 and IFN-γ overproduction in VD. Based on the correlations, higher energy metabolism in the anterior brain regions was associated with activation of the neuroinflammatory process due to overproduction of IL-4 and IL-8. An increase in IL-2 concentrations was associated with a higher CD-potential level in the posterior regions of the brain.

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This work was supported was supported by a state contract with the East Siberian Institute of Medical and Environmental Research (Angarsk).

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  1. East-Siberian Institute of Medical and Ecological Research, Angarsk, Russia

    O. I. Shevchenko, O. L. Lakhman, G. M. Bodienkova & E. V. Boklazhenko

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  3. G. M. Bodienkova
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Statement of compliance with standards of research involving humans as subjects. All procedures performed in studies involving human participants were in accordance with the ethical standards of the 1964 Helsinki Declaration of the World Medical Association and its later amendments and “Regulations of Clinical Practice in the Russian Federation” established by Order no. 266 dated June 19, 2003 of the RF Ministry of Health. The study was approved by the Ethics Committee at the East Siberian Institute of Medical and Environmental Research (Angarsk). All individual participants involved in the study gave their informed consent for participation after being informed about the potential risks and benefits and the nature of the study.

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Translated by T. Tkacheva

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Shevchenko, O.I., Lakhman, O.L., Bodienkova, G.M. et al. Comparison of the Serum Concentrations of Several Cytokines and the Brain Distribution of a Direct Current Potential Level in Patients with Vibration Disease. Hum Physiol 48, 64–70 (2022). https://doi.org/10.1134/S0362119722010133

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  • DOI: https://doi.org/10.1134/S0362119722010133

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