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Association of Neuregulin-1β with Physiological Cardiac Hypertrophy Following Acute and Chronic Exercise in Athlete and Non-Athlete Women

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Abstract

Neuregulin-1β (NRG-1β) is associated with cardiomyocyte proliferation and cardioprotection. Therefore, in the present study, the effect of acute and chronic exercise on plasma levels of NRG-1β and its association with cardiac hypertrophy in athlete and non-athlete women was investigated. Eighteen sedentary and 18 athlete women performed the Bruce test on a treadmill (acute) and 12 thrice-weekly sessions of water aerobic exercise (chronic). Plasma levels of NRG-1β were measured in all participants before and immediately after acute exercise, as well as, 24h and 72h after chronic exercise using ELISA kit. Moreover, echocardiographic parameters were analyzed before and after the exercise. The athletes had higher man levels of left ventricular end-diastolic diameter index (LVEDDI) and left ventricular mass index (LVMI) compared to the non-athletes before exercise. Moreover, 12-week exercise could significantly increase LVEDDI levels only in the non-athlete group. Plasma levels of NRG-1β were significantly higher in athletes than non-athletes. We found that chronic but not acute exercise could significantly increase levels of NRG-1β in both groups. The levels of NRG-1β were significantly lower three days after chronic exercise in comparison with 24h post-exercise in the non-athlete group. Plasma levels of NRG-1β had positive correlations with LVEDDI and LVMI in both groups. In conclusion, this study showed that chronic exercise could increase plasma levels of NRG-1β. Furthermore, the positive correlation between NRG-1β levels and cardiac hypertrophy indices suggests a role for NRG-1 in exercise-induced hypertrophy.

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ACKNOWLEDGMENTS

The authors would like to thank all the participants in this study and also the staff of Seyed-al-Shohada Cardiac Specialized Hospital for clinical data collection.

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Authors and Affiliations

  1. Department of Physical Education, Faculty of Sport Sciences, Urmia University, Urmia, Iran

    R. Mohammadzadeh, M. R. Zolfaghari &  P. Zolfaghar Didani

  2. Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

    S. Nikanfar

  3. Cardiology Department, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran

    K. Khademvatani

  4. Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

    A. Fattahi

Authors
  1. R. Mohammadzadeh
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  2. M. R. Zolfaghari
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  3. S. Nikanfar
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  4. K. Khademvatani
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  5. P. Zolfaghar Didani
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  6. A. Fattahi
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Corresponding authors

Correspondence to M. R. Zolfaghari or A. Fattahi.

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COMPLIANCE WITH ETHICAL STANDARDS

Before the initiation of the study, all participants received an explanation of the procedure and the risks that would later be faced in their participation and they provided informed consent to participate in this study. All procedures were in accordance with the Declaration of Helsinki.

CONFLICTS OF INTEREST

The authors declare that they have no conflict of interest.

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Mohammadzadeh, R., Zolfaghari, M.R., Nikanfar, S. et al. Association of Neuregulin-1β with Physiological Cardiac Hypertrophy Following Acute and Chronic Exercise in Athlete and Non-Athlete Women. Hum Physiol 48, 102–107 (2022). https://doi.org/10.1134/S036211972201011X

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  • DOI: https://doi.org/10.1134/S036211972201011X

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