Skip to main content
SpringerLink
Log in

Clinical–Neurobiological Correlations in Female Adolescents with Non-Suicidal Self-Injurious Behavior

Human Physiology Aims and scope Submit manuscript

Abstract

The relationships of quantitative clinical, EEG, and neuroimmunological parameters were analyzed in 40 female adolescent patients with depressive conditions and non-suicidal self-injurious behavior (NSSI) before starting a course of therapy in order to clarify the role of neuro-immune interactions in the pathogenesis of NSSI. The findings confirmed that neuroinflammation processes are involved in the pathogenesis of depression and NSSI and influence the EEG parameters. The structure of clinical–neurobiological correlations revealed in the study indicates that neuroinflammation processes in depressive patients with NSSI are relatively mild or compensated for by anti-inflammatory mechanisms and are accompanied by more subtle rearrangements of the EEG frequency structure and topography, in contrast to macroinflammation observed in encephalitis and meningitis and associated with an increase in slow-wave EEG activity. The results clarify the neurobiological factors of the pathogenesis of non-suicidal autoaggressive behavior in depressive adolescent patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price includes VAT (France)

Instant access to the full article PDF.

Institutional subscriptions

REFERENCES

  1. Preventing Suicide: A Global Imperative, Geneva: W.H.O. Press, 2014.

  2. Hamza, C.A., Stewart, S.L., and Willoughby, T., Examining the link between non-suicidal self-injury and suicidal behavior: a review of the literature and an integrated model, Clin. Psychol. Rev., 2012, vol. 32, no. 6, p. 482.

    Article  Google Scholar 

  3. Victor, S.E. and Klonsky, E.D., Correlates of suicide attempts among self-injurers: a meta-analysis, Clin. Psychol. Rev., 2014, vol. 34, no. 4, p. 282.

    Article  Google Scholar 

  4. Klyushnik, T.P., Zozulya, S.A., Androsova, L.V. et al., Immunological monitoring of endogenous attack-like psychoses, Zh. Nevropatol. Psikhiatr. im. S.S. Korsakova, 2014, vol. 114, no. 2, p. 37.

    Article  Google Scholar 

  5. Simashkova, N.V., Klyushnik, T.P., Koval’-Zaitsev, A.A., and Yakupova, L.P., Multidisciplinary clinical and psychological aspects of diagnosis of infantile autism and early-onset schizophrenia, Autizm Narusheniya Razvit., 2016, vol. 14, no. 4, p. 51.

    Google Scholar 

  6. Klyushnik, T.P., Androsova, L.V., and Mikhailova, N.M., Systemic inflammatory markers in age-associated cognitive impairment and Alzheimer’s disease, Zh. Nevropatol. Psikhiatr. im. S.S. Korsakova, 2017, vol. 117, no. 7, p. 74.

    Article  Google Scholar 

  7. Müller, N., Inflammation in schizophrenia: pathogenetic aspects and therapeutic considerations, Schizophr. Bull., 2018, vol. 44, no. 5, p. 973.

    Article  Google Scholar 

  8. Fond, G., Lançon, C., Korchia, T., et al., The role of inflammation in the treatment of schizophrenia, Front. Psychiatry, 2020, vol. 11, p. 160.

    Article  Google Scholar 

  9. Klyushnik, T.P., Smulevich, A.B., Zozulya, S.A., and Voronova, E.I., Neurobiology of schizophrenia (to the construction of clinical and biological model), Psikhiatriya, 2021, vol. 19, no. 1, p. 6.

    Article  Google Scholar 

  10. Lindquist, D., Janelidze, S., Hagell, P., et al., Interleukin-6 is elevated in the cerebrospinal fluid of suicide attempters and related to symptom severity, Biol. Psychiatry, 2009, vol. 66, no. 3, p. 287.

    Article  Google Scholar 

  11. Sublette, M.E., Galfalvy, H.C., Fuch, S.D., et al., Plasma kynurenine levels are elevated in suicide attempters with major depressive disorder, Brain Behav. Immun., 2011, vol. 25, no. 6, p. 1272.

    Article  CAS  Google Scholar 

  12. O’Donovan, A., Rush, G., Hoatam, G., et al., Suicidal ideation is associated with elevated inflammation in patients with major depressive disorder, Depression Anxiety, 2013, vol. 30, no. 4, p. 307.

    Article  Google Scholar 

  13. Falcone, T., Fazio, V., Lee, C., et al., Serum S100B: a potential biomarker for suicidality in adolescents? PLoS One, 2010, vol. 5, no. 6, p. e11089.

    Article  Google Scholar 

  14. Kim, J.S., Kang, E.S., Bahk, Y.C., et al., Exploratory analysis of behavioral impulsivity, proinflammatory cytokins, and resting-state frontal EEG activity associated with non-suicidal self-injury in patients with mood disorder, Front. Psychiatry, 2020, vol. 11, p. 124.

    Article  Google Scholar 

  15. Westmoreland, B., The EEG in cerebral inflammatory processes, in Electroencephalography: Basic Principles, Clinical Applications, and Related Fields, Nieder-meyer, E. and Lopes Da Silva, F., Eds., Baltimore: Williams & Wilkins, 1999, p. 302.

    Google Scholar 

  16. Iznak, A.F., Iznak, E.V., Klyushnik, T.P., et al., Neurophysiological and neuroimmunological indicators for predicting the effectiveness of therapy for affective-delusional states within paroxysmal schizophrenia, Psikhiatriya, 2014, no. 2 (62), p. 47.

  17. Iznak, A.F., Iznak, E.V., Klyushnik, T.P., et al., Regression models of the relationship of clinical and neurobiological indicators in the treatment of manic-delusional states in the framework of attack-like schizophrenia, Zh. Nevropatol. Psikhiatr. im. S.S. Korsakova, 2016, vol. 116, no. 3, p. 24.

    Google Scholar 

  18. Iznak, A.F., Iznak, E.V., Klyushnik, T.P., et al., Neurobiological parameters in quantitative prediction of treatment outcome in schizophrenic patients, J. Integr. Neurosci., 2018, vol. 17, no. 3, p. 221.

    Article  Google Scholar 

  19. Damyanovich, E.V., Iznak, E.V., Oleichik, I.V., and Iznak, A.F., EEG features in adolescent females with self-injurious behavior in structure of endogenous depressions, Psikhiatriya, 2020, vol. 18, no. 2, p. 39.

    Article  Google Scholar 

  20. Iznak, E.V., Damyanovich, E.V., Levchenko, N.S., et al., EEG asymmetries in depressive female adolescents with different kinds of auto-aggressive behavior, Psikhiatriya, 2020, vol. 18, no. 3, p. 14.

    Article  Google Scholar 

  21. Iznak, A.F., Iznak, E.V., Damyanovich, E.V., and Oleichik, I.V., Differences of EEG frequency and Spatial Parameters in Depressive Female Adolescents with Suicidal Attempts and Non-Suicidal Self-Injuries, Clin. EEG Neurosci., 2021. https://doi.org/10.1177/1550059421991685

  22. ICD-10. International Statistical Classification of Diseases and Related Health Problems 10th Revision Classification of Mental and Behavioral Disorders. Clinical Descriptions and Diagnostic Guidance, Geneva: World Health Org., 2019.

  23. Hamilton, M.Y., Psychopathology of depressions: quantitative aspects, in Psychopathology of Depression, Helsinki: WHO Press, 1980, p. 201.

    Google Scholar 

  24. Mitrofanov, A.A., Komp’yuternaya sistema ananliza i topograficheskogo kartirovaniya elektricheskoi aktivnosti mozga s neirometricheskim bankom EEG-dannykh (opisanie i primenenie) (Computer System of Analysis and Topographic Mapping of Brain Electric Activity with Neurometric EEG Database: Description and Application), Moscow, 2005.

  25. Klyushnik, T.P., Zozulya, S.A., Androsova, L.V., et al., Laboratornaya diagnostika v monitoringe patsientov s endogennymi psikhozami (“Neiro-immuno-test”). Meditsinskaya tekhnologiya (Laboratory Diagnostics in Monitoring of Patients with Endogenous Psychoses (“Neuro-Immune-Test”). Medical Technology), Moscow: Med. Inf. Agentstvo, 2014.

  26. Davidson, R.J., Affective style and affective disorders: Perspectives from affective neuroscience, Cognit. Emotion, 1998, vol. 12, no. 3, p. 307.

    Article  Google Scholar 

  27. Iznak, A.F., Iznak, E.V., and Sorokin, S.A., Changes in EEG and reaction time during the treatment of apathetic depression, Neurosci. Behav. Physiol., 2013, vol. 43, no. 1, p. 79.

    Article  Google Scholar 

  28. Russ, M.J., Campbell, S.S., and Kakuma, T., EEG theta activity and pain insensitivity in self-injurious borderline patients, Psychiatry Res., 1999, vol. 89, no. 3, p. 201.

    Article  CAS  Google Scholar 

  29. Lee, S.M., Jang, K.I., and Chae, J.H., Electroencephalographic correlates of suicidal ideation in the theta band, Clin. EEG Neurosci., 2017, vol. 48, no. 5, p. 316.

    Article  Google Scholar 

  30. Janis, I.B. and Nock, M.K., Are self-injurers impulsive? Results from two behavioral laboratory studies, Psychiatry Res., 2009, vol. 169, no. 3, p. 261.

    Article  Google Scholar 

  31. Lykissas, M.G., Batistatou, A.K., Charalabopou-los, K.A., and Beris, A.E., The role of neurotrophins in axonal growth, guidance, and regeneration, Curr. Neurovasc. Res., 2007, vol. 4, no. 2, p. 143.

    Article  CAS  Google Scholar 

  32. Fuchs, E., Neuroplasticity—A new approach to the pathophysiology of depression, in Neuroplasticity: New Biochemical Mechanisms, Costa e Silva, J.A., Macher, J.P., and Olié, J.P., Eds., Tarporley: Springer-Verlag, 2011, p. 1.

Download references

Funding

This work was supported by the Russian Foundation for Basic Research (project no. 20-013-00129a).

Author information

Authors and Affiliations

  1. Mental Health Research Centre, Moscow, Russia

    E. V. Iznak, A. F. Iznak, I. V. Oleichik & S. A. Zozulya

Authors
  1. E. V. Iznak
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. F. Iznak
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. I. V. Oleichik
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. A. Zozulya
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to E. V. Iznak.

Ethics declarations

Conflict of interests. The authors declare that they have no conflict of interest.

Statement of compliance with standards of research involving humans as subjects. The study was carried out in accordance with the ethical standards of the 1964 Helsinki Declaration and its later amendments and was approved by the local Ethics Committee at the Mental Health Research Centre (Moscow). All individual participants involved in the study voluntarily signed the informed consent document after being informed about the potential risks and benefits and the nature of the study.

Additional information

Translated by T. Tkacheva

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Iznak, E.V., Iznak, A.F., Oleichik, I.V. et al. Clinical–Neurobiological Correlations in Female Adolescents with Non-Suicidal Self-Injurious Behavior. Hum Physiol 47, 606–611 (2021). https://doi.org/10.1134/S0362119721050054

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0362119721050054

Keywords:

Search

Navigation