Abstract
The paper describes the history of development and improvement of the means of the Russian system of countermeasures against the negative effects of space flights over the past two decades and the contribution of Inesa B. Kozlovskaya to this field. The results of physiological tests of the efficacy of new and upgraded means under the conditions of ground-based model experiments and the prospects for the development of the countermeasure system are described.
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REFERENCES
Kozlovskaya, I., Dmitrieva, I., Grigorieva, L., et al., Gravitational mechanisms in the motor system. Studies in real and simulated weightlessness, in Stance and Motion: Facts and Concepts, Gurfinkel, V., Ioffe, M.E., Massion, J., and Roll, J.P., Eds., New York: Springer-Verlag, 1988, p. 37.
Kozlovskaya, I.B., Gravitational mechanisms in the locomotor system, in Sovremennyi kurs klassicheskoi fiziologii. Izbrannye lektsii (Modern Course of Traditional Physiology: Selected Lecturers), Natochin, Yu.V. and Tkachuk, V.A., Eds., Moscow: GEOTAR-Media, 2007, p. 1.
Grigor’ev, A.I., Kozlovskaya, I.B., and Shenkman, B.S., The role of support afferentation in the organization of the tonic muscular system, Ross. Fiziol. Zh. im. I.M. Sechenova, 2004, vol. 90, no. 5, p. 507.
Kozlovskaya, I.B., Sayenko, I.V., Sayenko, D.G., et al., Role of support afferentation in control of the tonic muscle activity, Acta Astronaut., 2007, vol. 60, nos. 4–7, p. 285.
Kozlovskaya, I.B., Yarmanova, E.N., and Fomina, E.V., The Russian system of preventive countermeasures: its present and future, Hum. Physiol., 2015, vol. 41, no. 7, p. 704.
Kozlovskaya, I.B., Yarmanova, E.N., Yegorov, A.D., et al., Russian countermeasure systems for adverse effects of microgravity on long-duration ISS flights, Aerospace Med. Hum. Perform., 2015, vol. 86, no. 12, p. 24.
Fomina, E.V., Lysova, N.Yu., and Savinkina, A.O., Axial load during performing locomotor training in microgravity as a factor of hypogravity countermeasure efficiency, Hum. Physiol., 2018, vol. 44, no. 1, p. 47.
Grigoriev, A.I., Kozlovskaya, I.B., Sawin, C.F., and Mueller, S.A., Countermeasures to short-term and long-term space flight, in Space Biology and Medicine, Vol. 4: Health, Performance, and Safety of Space Crews, Reston, VA: Am. Inst. Aeronaut. Astronaut., 2004, p. 157.
Barer, A.S., Kozlovskaya, I.B., Tikhomirov, E.P., et al., Effect of loading suit “Penguin” on human metabolism during movements, Aviakosm. Ekol. Med., 1998, vol. 32, no. 4, p. 4.
Shigueva, T.A., Zakirova, A.Z., Tomilovskaya, E.S., and Kozlovskaya, I.B., Effect of loading suit “Penguin” on the characteristics of the spinal reflex in supportless conditions, Materialy XI Mezhdunarodnoi nauchno-prakticheskoi konferentsii “Pilotiruemye polety v kosmos,” Zvezdnyi gorodok, Moskovskaya oblst, 10–12 noyabrya 2015 g. (Proc. XI Int. Sci.-Pract. Conf. “Manned Space Flights,” Zvezdny Gorodok, Moscow Oblast, November 10–12, 2015), Zvezdny Gorodok, 2015, p. 483.
Tomilovskaya, E.S., Rukavishnikov, I.V., Shigueva, T.A., et al., Role of axial and support unloading in development of hypogravitational motor syndrome, Proc. 39th ISGP Meeting & ESA Life Sciences Meeting, Noordwijk, 2018.
Suvorov, A.V., Pamova, A.P., and Fedorovich, A.A., Specifics of microcirculation in the conditions of “dry” immersion, Aviakosm. Ekol. Med., 2017, vol. 51, no. 6, p. 32.
Shenkman, B.S., Vinogradova, O.L., Mazin, M.G., et al., Physiological cost of physical exercise and mitochondrial volume in working muscles of subjects exposed to long-term hypokinesia: effects of local resistance exercise, Hum. Physiol., 2003, vol. 29, no. 2, p. 195.
Ohira, Y., Yoshinaga, T., Ohara, M., et al., Myonuclear domain and myosin phenotype in human soleus after bed rest with or without loading, J. Appl. Physiol., 1999, vol. 87, no. 5, p. 1776.
Cherepakhin, M.A., Kakurin, L.I., Il’ina-Kakueva, E.I., and Fedorenko, G.T., Evaluation of the effectiveness of electrical muscle stimulation toe prevent the disorders associated with long-term limitation of physical activity in men, Kosm. Biol. Aviakosm. Med., 1977, vol. 11, p. 64.
Koryak, Y.A., Kozlovskaya, I.B., and Khimoroda, N.N., Low-frequency neuromuscular electrical stimulation training of human skeletal muscles in conditions of gravitational unloading, Eur. J. Nat. Hist., 2008, no. 1, p. 86.
Kozlovskaya, I.B., Fundamental and applied objectives of investigation in dry immersion, Hum. Physiol., 2010, vol. 36, no. 7, p. 808.
Eshmanova, A.K., Ivanov, G.G., Kabulova, A.Z., et al., ECG high resolution and dispersion ECG mapping under the influence of amlodipine and myostimulation against a background of a 7-day dry immersion, Aviakosm. Ekol. Med., 2009, vol. 43, no. 1, p. 40.
Solovieva, A., Sedova, E., Tomilovskaya, E., et al., Functional activity of the liver under the conditions of immersion and effects of the countermeasures, Hum. Physiol., 2016, vol. 42, no. 7, p. 740.
Mayr, W., Freilinger, G., Rafolt, D., et al., Functional electrical stimulation (FES) as a countermeasure against muscular atrophy in long-term space flights—first application on board of MIR-Station, Proc. 5th Annual Conf. of the International Functional Electrical Stimulation Society and 6th Triennial Conf. “Neural Prostheses: Motor Systems,” Aalborg, 2000, p. 27.
Rafolt, D., Mayr, W., Freilinger, G., et al., Functional electrical stimulation (FES) to prevent muscular atrophy in long-term space flights, Biomed. Techn., 2009, vol. 45, no. 1, p. 279.
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Yarmanova, E.N. Development and Improvement of Countermeasures against Negative Effects of Weightlessness in Long-Term Space Flights on Board International Space Station. Hum Physiol 47, 328–334 (2021). https://doi.org/10.1134/S036211972103018X
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DOI: https://doi.org/10.1134/S036211972103018X