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The Role of Gap Junctions in Endothelial–Stromal Cell Interactions

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Abstract

Gap junctions are one of the most highly specialized intercellular communications providing not only electrical coupling but also metabolic cooperation between cells due to the direct exchange of cytoplasmic components. Interaction of the endothelial and stromal cells through gap junctions significantly contributes to the control of the state of the vascular wall, as well as to the regulation of homeostasis of other tissues both under physiological and pathological conditions. This review summarizes the modern data on homocellular gap junctions in endothelial cells and stromal progenitors of different commitment, as well as on the role of heterocellular communication in the interplay of these cell types.

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Funding

The reported study was funded by the Russian Foundation for Basic Research (RFBR) (project number 20-015-00075) and the program of the President of the Russian Federation for State Support of Young Scientists–Candidates of Sciences (project no. MK-808.2020.4).

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Authors and Affiliations

  1. Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia

    M. I. Ezdakova, D. K. Matveeva & E. R. Andreeva

  2. Moscow State University, Moscow, Russia

    S. V. Buravkov

Authors
  1. M. I. Ezdakova
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  2. D. K. Matveeva
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  3. S. V. Buravkov
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  4. E. R. Andreeva
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Corresponding author

Correspondence to E. R. Andreeva.

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The authors declare no obvious and potential conflicts of interest related to the publication of this article. This article does not contain any studies involving animals or human participants performed by the author.

CONFLICT OF INTERESTThe authors declare no obvious and potential conflicts of interest related to the publication of this article.

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Translated by M. Batrukova

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Ezdakova, M.I., Matveeva, D.K., Buravkov, S.V. et al. The Role of Gap Junctions in Endothelial–Stromal Cell Interactions. Hum Physiol 47, 352–362 (2021). https://doi.org/10.1134/S036211972103004X

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  • DOI: https://doi.org/10.1134/S036211972103004X

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