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Control the Functional State of the Brain Based on the Dynamics of Integral Parameters of Multichannel EEG in Human under Acute Hypoxia

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Abstract

Development of methods for monitoring the functional state (FS) of people under extreme conditions is of great applied significance. The aim of this study was to investigate the dynamics of integral EEG parameters in individuals with different levels of hypoxia sensitivity and tolerance during their exposure to oxygen deficiency. Acute hypoxia was induced by a mixture of 8% oxygen in nitrogen for breathing. The study cohort was composed of 41 male participants aged from 19 to 45 years. We recorded a complex of physiological indices, as well as multichannel EEGs, based on which the structure function and the integral normalized parameters were calculated. These parameters were used as a measure of temporal (Pt) and spatial (Ps) connectivity between oscillations of brain potentials. The extreme values of parameters, 0 and 1, corresponded to the completely deterministic and “random” temporal and spatial organization of the EEG. A decrease in Pt, as hypoxia deepened, indicated a growth in the temporal connectivity and inertness in the EEG, which characterized a decrease in the physiological lability and the FS of the brain. Significant changes in Ps, which indicated an increase in the degree of EEG spatial connectivity, were recorded only in individuals with low hypoxia tolerance in a precollaptoid state. The use of the normalized Pt and Ps parameters allowed us to classify the subjects by the degree of their sensitivity to hypoxia and identify individuals with high sensitivity, under a relatively small fall in hemoglobin oxygen saturation (SaO2), and persons resistant to hypoxia even at low levels of SaO2, which is important for the selection of persons exposed to hypoxia by occupation.

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ACKNOWLEDGMENTS

The authors thank E.A. Burykh, MD, senior researcher of the Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, for his important contribution to the conduction of experimental investigations.

Funding

The study was supported by the Program of Research of the Presidium of the Russian Academy of Sciences no. 18 (АААА-А18-118013190226-4).

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Authors and Affiliations

  1. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, 194223, St. Petersburg, Russia

    V. P. Rozhkov, M. I. Trifonov & S. I. Soroko

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  1. V. P. Rozhkov
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  2. M. I. Trifonov
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  3. S. I. Soroko
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Correspondence to V. P. Rozhkov.

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COMPLIANCE WITH ETHICAL STANDARDS

All investigations were conducted in conformity with the principles of biomedical ethics stipulated under the 1964 Helsinki Declaration and its subsequent revisions and approved by the Commission on Ethics of the Academic Council, Sechenov Institute of Evolutionary Physiology and Biochemistry (IEPhB), Russian Academy of Sciences (RAS) (St. Petersburg).

INFORMED CONSENT

Each participant in the study gave his informed voluntary written consent signed by him after informing him about potential risks, as well as about the nature of the forthcoming study.

CONFLICTS OF INTERESTS

The authors declare the absence of apparent and potential conflicts of interests related to the publication of this study.

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Translated by N. Tarasyuk

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Rozhkov, V.P., Trifonov, M.I. & Soroko, S.I. Control the Functional State of the Brain Based on the Dynamics of Integral Parameters of Multichannel EEG in Human under Acute Hypoxia. Hum Physiol 47, 1–13 (2021). https://doi.org/10.1134/S0362119721010114

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