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The Effect of Afferentation of Various Sensory Systems on the Otolith-Ocular Reflex in a Real and Simulated Weightlessness

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Abstract

Weightlessness can affect the vestibular function, primarily the otolith function, both directly due to the loss of gravitational influence and by eliminating the support and minimizing proprioceptive afferentation, influencing indirectly through the central integrative multisensory structures of the central nervous system (CNS), where the convergence of afferent signals of various sensory modality (primarily visual, vestibular, support and motor) occurs. All this prompted the study of the influence of various afferentations on the otolith-ocular reflex under the conditions of real and simulated weightlessness. Using the video oculography method, 58 Russian cosmonauts, members of long-term missions to the ISS (125–219 days, ~175 days on average), were examined by a static torsional otolith-cervical-ocular reflex (OCOR) with a head tilt to the shoulder at an angle of 30 deg, the otolith-ocular reflex (OOR) when the body is tilted at an angle of 30 deg, and the otolith-ocular reflex when exposed to centrifugal acceleration using a centrifuge (OORCF). Nine out of 58 cosmonauts were examined in microgravity (175 days) as part of the Virtual space experiment (Stage 1). The study of simulation of the spaceflight (SF) factors involved 30 subjects during five- or seven-day horizontal “dry” immersion (DI) and 12 subjects in 60-day head-down tilt (–8 deg) bed rest (BR). The procedure and the corresponding hardware and software used both in studies with the participation of cosmonauts and in model experiments were completely identical. In weightlessness, throughout the whole SF, all the cosmonauts surveyed had a significant OCOR decrease with the presence (from 11 to 55%, depending on the flight day) of the atypical (inversion or absence) otolith-ocular reflex. After SF, on days 1–4 of examination, 80% of the cosmonauts exhibited a significant OCOR/OOR decrease; 34% of the cosmonauts had atypical (inversion or absence of the otolith reflex) vestibular reactions, while no differences were found between OCOR and OOR. Statistically significant differences were found between the values ​of the OCOR/OOR and OORCF reflexes before and on days 4–5, 9–12 after SF. On days 2–3 after SF, no difference between OORCF and OCOR/OOR was observed. The return of the otolith reflex to the baseline took place only on day 9 after SF. The OCOR/OOR study on days 1–3 after DI showed that the otolith-ocular reflex in 47% of those examined was significantly reduced; in 13% of the subjects atypical reactions (absence or inversion of the reflex) were recorded. On days 4–6 after DI, OCOR/OOR returned to the baseline in all subjects. Analysis of OCOR/OOR after the BR experiment showed that only 14% of the surveyed had a significant decrease in OCOR/OOR on day 1 after the experiment. The atypical form of OCOR/OOR (inversion or complete absence of the otolith reflex) after BR was not revealed in contrast to the testers after DI. The results obtained demonstrated the influence of nonvestibular afferentation on the intensity of the otolith-ocular reflex and its dependence on other sensory inputs.

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Funding

The study was supported by the base funding of the RAS on topic 63.1.

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Authors and Affiliations

  1. Institute of Biomedical Problems, Russian Academy of Sciences, 123007, Moscow, Russia

    I. A. Naumov, L. N. Kornilova, D. O. Glukhikh, G. A. Ekimovskiy & I. B. Kozlovskaya

  2. Gagarin Research & Test Cosmonaut Training Center (GCTC), 141160, Zvezdnyi Gorodok, MoscowRegion, Russia

    A. V. Vasin

  3. Antwerp University Research Сentre for Equilibrium and Aerospace (AUREA), 2000, Antwerpen, Belgium

    F. L. Wuyts

Authors
  1. I. A. Naumov
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  2. L. N. Kornilova
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  3. D. O. Glukhikh
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  4. G. A. Ekimovskiy
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  5. I. B. Kozlovskaya
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  6. A. V. Vasin
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Correspondence to I. A. Naumov or L. N. Kornilova.

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COMPLIANCE WITH ETHICAL STANDARDS

All procedures performed in studies involving human participants were in accordance with the biomedical ethics principles formulated in the 1964 Helsinki Declaration and its later amendments and approved by the local bioethics commission of the Institute of Biomedical Problems, Russian Academy of Sciences (Moscow), and Human Research Multilateral Review Board.

CONFLICT OF INTEREST

The authors declare that they have no conflict of interest.

INFORMED CONSENT

Informed written consent was obtained from all individual participants involved in the study and signed by them after being explained the potential risks and advantages, as well as the essence of the future study, with strict adherence to all prescribed rules and conditions of conduct on the days of the study, including SE sessions on board the ISS.

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Translated by E. Babchenko

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Naumov, I.A., Kornilova, L.N., Glukhikh, D.O. et al. The Effect of Afferentation of Various Sensory Systems on the Otolith-Ocular Reflex in a Real and Simulated Weightlessness. Hum Physiol 47, 70–78 (2021). https://doi.org/10.1134/S0362119720060080

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