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EPAC Proteins and Their Role in the Physiological and Pathological Processes in the Cardiovascular System. Part II. The role of EPAC Proteins in the Physiology and Pathology of the Heart

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Abstract

The second part of the review presents modern ideas about vision of the role of Epac proteins in the regulation of inotropic and rhythmic functions of the heart, intercellular coupling of cardiomyocytes and their apoptosis. The contribution of Epac proteins to the development of hypertrophy, fibrosis, and myocardial remodeling, as well as their role in the genesis of acute ischemic damage to the heart muscle and cardiac arrhythmias, is examined in detail.

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ACKNOWLEDGMENTS

We are deeply grateful to Corresponding Member of the RAS Yu.V. Vakhitova (Zakusov Research Institute of Pharmacology, Moscow) for her advisory assistance in the work on the literature review and V.V. Barchukov (Zakusov Research Institute of Pharmacology, Moscow) for his help in presenting the results of the study.

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  1. Zakusov Institute of Pharmacology, Moscow, Russia

    S. A. Kryzhanovskii, T. D. Nikiforova, M. B. Vititnova & A. D. Durnev

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  1. S. A. Kryzhanovskii
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  2. T. D. Nikiforova
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Kryzhanovskii, S.A., Nikiforova, T.D., Vititnova, M.B. et al. EPAC Proteins and Their Role in the Physiological and Pathological Processes in the Cardiovascular System. Part II. The role of EPAC Proteins in the Physiology and Pathology of the Heart. Hum Physiol 46, 443–464 (2020). https://doi.org/10.1134/S0362119720040076

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