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A Search for Early Predictors of Mental and Speech Disorders: Neurophysiological Aspects

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Abstract

Data from neurophysiological examinations were summarized for children with mental development disorders of perinatal genesis. Hypothetical sources of slow activity were found in the frontotemporal cortex bilaterally. An increase in the power of slow components was shown to correlate with the severity of mental developmental disorders. New data were obtained to indicate that local and distributed (“global”) sources of EEG rhythms have a potential as neuromarkers of psychoverbal retardation in early ontogeny. A high level accuracy was observed for a classification of the children on the basis of these potential neuromarkers.

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Authors and Affiliations

  1. Bechtereva Institute of the Human Brain, Russian Academy of Sciences, St. Petersburg, Russia

    N. Yu. Kozhushko & S. A. Evdokimov

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  1. N. Yu. Kozhushko
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  2. S. A. Evdokimov
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Correspondence to N. Yu. Kozhushko.

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Statement of compliance with standards of research involving humans as subjects. All procedures were in accordance with the ethical standards of the 1964 Helsinki Declaration and its later amendments and were approved by the local Ethics Committee at the N.P. Bechtereva Institute of the Human Brain (St. Petersburg). The parents of all individual participants involved in the study voluntarily gave their written informed consent for participation after being informed about potential risk and benefits and the nature of the study.

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Translated by T. Tkacheva

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Kozhushko, N.Y., Evdokimov, S.A. A Search for Early Predictors of Mental and Speech Disorders: Neurophysiological Aspects. Hum Physiol 46, 288–294 (2020). https://doi.org/10.1134/S0362119720030093

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  • DOI: https://doi.org/10.1134/S0362119720030093

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