Abstract
Urine chromatography–mass spectrometry and a heart rate variability (HRV) analysis were performed in 13 healthy males (age 28 ± 4 years, height 174 ± 1 cm, weight 67.9 ± 1.5 kg). Mathematical and bioinformatics analyses identified the proteins that are associated with the condition of the cardiovascular system and the autonomic regulation of the heart rate in the total protein aggregate. The set included serotransferrin, tyrosine-protein kinase receptor UFO, prostatic acid phosphatase, secreted and transmembrane protein 1, cell adhesion molecule 4, galectin-3-binding protein, immunoglobulin heavy constant alpha 1, matrix remodeling-associated protein 8, and biotinidase. Associations were for the first time studied for protein markers of the heart rate autonomic regulation. Proteomics data were used to describe the indicators of the heart rate physiological regulation in the urine proteome of healthy young males.
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Funding
This work was supported by Basic Programs 64.1 and 65.3 of the Russian Academy of Sciences for the period from 2013 to 2020. The part of research related to the high resolution mass spectrometry study of urine proteome was supported by Russian Foundation for Basic Research (grant no. 18-34-00524).
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Statement of compliance with standards of research involving humans as subjects. All procedures performed in studies involving human participants were in accordance with the ethical standards of the 1964 Helsinki Declaration and its later amendments and were approved by the Ethics Committee at the Institute of Biomedical Problems (Russian Academy of Sciences, Moscow). All individual participants involved in the study voluntarily gave their written informed consent after being informed about the potential risks and benefits and the study nature.
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Translated by T. Tkacheva
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Rusanov, V.B., Pastushkova, L.H., Goncharova, A.G. et al. Reflection of Heart Rate Physiological Regulation Parameters in the Urinary Proteome in Healthy Young Males. Hum Physiol 46, 182–190 (2020). https://doi.org/10.1134/S0362119720020152
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DOI: https://doi.org/10.1134/S0362119720020152