Systematic Review on 25-HydroxyvitaminD Levels in Various Populations of the Russian North


We analyzed published data on the levels of serum 25(OH)D in apparently healthy individuals from the Russian Far North. The total sample included 2061 subjects of various age and ethnic groups. The serum levels of 25(OH)D and its age dynamics in the northerners living in towns are similar to those of the inhabitants of the temperate climate zone of Russia. Data on the age-related changes in the vitamin D status of the indigenous Arctic people with the traditional lifestyle are scanty. Serum 25(OH)D concentrations in the indigenous and alien population of the high-latitude regions reflect the seasonal changes in the daylight duration. The level of vitamin D decreases in winter and reaches minimum in February, i.e., after the end of the polar night. We compared data on rural Russian and indigenous people and found ethnic differences in the 25(OH)D concentrations; however, the vitamin D status of various indigenous groups of the Russian North is poorly studied. We could not find publications that analyze the 25(OH)D concentrations along with the direct assessment of food consumption. The available data do not contradict the opinion that the traditional food products are beneficial. However, there are no studies to support this opinion. There are little data on the effect of foods from marine mammal catch, marine and freshwater fishery, and venison on the vitamin D status of the indigenous people of the Russian North.

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  1. 1

    Göring, H. and Koshuchowa S., Vitamin D—the sun hormone. Life in environmental mismatch, Biochemistry (Moscow), 2015, vol. 80, no. 1, p. 8.

    PubMed  Google Scholar 

  2. 2

    Mostafa, W.Z. and Hegazy, R.A., Vitamin D and the skin: focus on a complex relationship, J. Adv. Res., 2015, vol. 6, p. 793.

    CAS  Article  Google Scholar 

  3. 3

    Huotari, A. and Herzig, K.H., Vitamin D and living in northern latitudes: an endemic risk area for vitamin D deficiency, Int. J. Circumpolar Health, 2008, vol. 67, p. 164.

    Article  Google Scholar 

  4. 4

    Engelsen, O., The relationship between ultraviolet radiation exposure and vitamin D status, Nutrients, 2010, vol. 2, no. 5, p. 482.

    CAS  Article  Google Scholar 

  5. 5

    Zerwekh, J.E., Blood biomarkers of vitamin D status, Am. J. Clin. Nutr., 2008, vol. 87, no. 4, p. 1087S.

    CAS  Article  Google Scholar 

  6. 6

    Wallace, A.M., Gibson, S., de la Hunty, A., et al., Measurement of 25-hydroxyvitamin D in the clinical laboratory: current procedures, performance characteristics and limitations, Steroids, 2010, vol. 75, no. 7, p. 477.

    CAS  Article  Google Scholar 

  7. 7

    Kozlov, A.I. and Vershubskaya, G.G., Vitamin D and the health of northern residents, Nasledie Beringii, 2016, no. 3, p. 344.

  8. 8

    Blazheevich, N.V., Spirichev, V.B., Pereverzeva, O.G., et al., Calcium-phosphorus metabolism and the provision of vitamin D in the Far North, Vopr. Pitan., 1983, no. 1, p. 17.

  9. 9

    Potolitsyna, N.N., Boiko, E.R., Orr, P., and Kozlov, A.I. Provision of vitamin D of the indigenous people of the European North of Russia, Vopr. Pitan., 2010, vol. 79, no. 4, p. 63.

    CAS  PubMed  Google Scholar 

  10. 10

    Kozlov, A., Khabarova, Yu., Vershubsky, G., et al., Vitamin D status of northern indigenous people of Russia leading traditional and “modernized” way of life, Int. J. Circumpolar Health, 2014, vol. 73, p. 26038.

    Article  Google Scholar 

  11. 11

    Lehtonen-Veromaa, M., Mottonen, T., Irjala, K., et al., Vitamin D intake is low and hypovitaminosis D common in healthy 9- to 15-year-old Finnish girls, Eur. J. Clin. Nutr., 1999, vol. 53, no. 4, p. 746.

    CAS  Article  Google Scholar 

  12. 12

    Lamberg-Allardt, C.J., Outila, T.A., Kärkkainen, M.U., et al., Vitamin D deficiency and bone health in healthy adults in Finland: could this be a concern in other parts of Europe? J. Bone Miner. Res., 2001, vol. 16, no. 11, p. 2066.

    CAS  Article  Google Scholar 

  13. 13

    Cutolo, M., Otsa, K., Laas, K., et al., Circannual vitamin D serum levels and disease activity in rheumatoid arthritis: Northern versus Southern Europe, Clin. Exp. Rheumatol., 2006, vol. 24, no. 6, p. 702.

    CAS  PubMed  Google Scholar 

  14. 14

    Brustad, M., Edvardsen, K., Wilsgaard, T., et al., Seasonality of UV-radiation and vitamin D status at 69 degrees North, Photochem. Photobiol. Sci., 2007, vol. 8, no. 6, p. 903.

    Article  Google Scholar 

  15. 15

    Holvik, K., Brunvand, L., Brustad, M., and Meyer, H.E., Vitamin D status in the Norwegian population, in Solar Radiation and Human Health, Bjertness, E., Ed., Oslo: Norw. Acad. Sci. Lett., 2008, p. 216.

    Google Scholar 

  16. 16

    Andersson, A., Bjork, A., Kristiansson, P., and Johansson, G., Vitamin D intake and status in immigrant and native Swedish women: a study at a primary health care centre located at 60°N in Sweden, Food Nutr. Res., 2013, no. 5, p. 20089.

  17. 17

    Lebrun, J.B., Moffatt, M.E., Mundy, R.J., et al., Vitamin D deficiency in a Manitoba community, Can. J. Publ. Health, 1993, vol. 84, no. 6, p. 394.

    CAS  Google Scholar 

  18. 18

    Rejnmark, L., Jorgensen, M.E., Pedersen, M.B., et al., Vitamin D insufficiency in Greenlanders on a westernized fare: ethnic differences in calcitropic hormones between Greenlanders and Danes, Calcif. Tissue Int., 2004, vol. 74, no. 3, p. 255.

    CAS  Article  Google Scholar 

  19. 19

    Hayek, J., Egeland, G., and Weiler, H., Vitamin D status of Inuit preschoolers reflects season and vitamin D intake, J. Nutr., 2010, vol. 140, no. 10, p. 1839.

    Article  Google Scholar 

  20. 20

    Frost, P., Vitamin D deficiency among northern native peoples: a real or apparent problem? Int. J. Circumpolar Health, 2012, vol. 71, p. 18001.

    Article  Google Scholar 

  21. 21

    Spasich, T.A., Lemeshevskaya, E.P., Reshetnik, L.A., et al., Hygienic significance of vitamin D deficiency in the population of the Irkutsk oblast and its prevention, Bull. Vost.-Sib. Nauchn. Tsentra Sib. Otd., Ross. Akad. Nauk, 2014, no. 6 (100), p. 44.

  22. 22

    Spasich, T.A., Reshetnik, L.A., Zhdanova, E.Yu., et al., Appropriate prevention of vitamin D deficiency in the population of the Irkutsk oblast, Acta Biomed. Sci., 2017, vol. 2, no. 5, part 2, p. 43.

  23. 23

    Göring, H. and Koshuchowa, S., Vitamin D deficiency in Europeans today and in Viking settlers of Greenland, Biochemistry (Moscow), 2016, vol. 81, no. 12, p. 1492.

    PubMed  Google Scholar 

  24. 24

    Kozlov, A.I., Kozlova, M.A., Vershubskaya, G.G., and Shilov, A.B., Zdorov’e korennogo naseleniya Severa RF: na grani vekov i kul’tur (Health of Indigenous People of the Russian North: On the Verge of Centuries and Cultures), Perm: Perm. Gos. Gumanit.-Pedagog. Univ., 2012.

  25. 25

    Kozlov, A.I. and Vershubskaya, G.G., Blood serum 25-hydroxyvitamin D in various populations of Russia, Ukraine, and Belarus: a systematic review with elements of meta-analysis, Hum. Physiol., 2017, vol. 43, no. 6, p. 135.

    Google Scholar 

  26. 26

    Dietary Reference Intakes for Calcium and Vitamin D. Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium, Ross, A.C., Taylor, C.L., Yaktine, A.L., and Del Valle, H.B., Eds., Washington, DC: Natl. Acad. Press, 2011.

  27. 27

    Malyavskaya, S.I., Kostrova, G.N., Lebedev, A.V., et al., Provision of vitamin D of young children of the Arkhangelsk oblast, Ekol. Chel., 2016, no. 11, p. 18.

  28. 28

    Malyavskaya, S.I., Kostrova, G.N., Lebedev, A.V., and Golysheva, E.V., Provision of vitamin D of different age groups of the population in Arkhangelsk, Ekol. Chel., 2016, no. 12, p. 37.

  29. 29

    Shkerskaya, N.Yu., Ruzhnikov, A.O., and Zykova, T.A., Vitamin D availability and bone metabolism in adolescents with dental diseases, Zemskii Vrach, 2014, vols. 3–4, no. 24, p. 47.

    Google Scholar 

  30. 30

    Krivoshapkina, D.M. and Khandy, M.V., The content of vitamin D in the blood serum of children in Yakutsk, Vopr. Sovrem. Pediatrii, 2006, no. 5, p. 295.

  31. 31

    Kozlov, A.I., Ateeva, Yu.A., Vershubskaya, G.G., and Ryzhaenkov, V.G., The content of vitamin D in school-age children in the Urals and North-West Russia, Pediatriya, 2012, no. 1, p. 144.

  32. 32

    Koman, I.E., Sychev, D.A., and Shikh, E.V., Influence of CYP2C9 gene polymorphism on vitamin D metabolism in Chukotka children, Ross. Vestn. Perinatol. Pediatr-., 2006, vol. 51, no. 1, p. 17.

    Google Scholar 

  33. 33

    Malyavskaya, S.I., Kostrova, G.N., Lebedev, A.V., et al., Vitamin D levels in various people of the city of Arkhangelsk, Ekol. Chel., 2018, no. 1, p. 60.

  34. 34

    Kozlov, A.I., Ateeva, Yu.A., Vershubskaya, G.G., et al., D-vitamin status of the population of the Perm krai, the Republics of Komi and Udmurtia, Vopr. Pita-n., 2013, vol. 82, no. 2, p. 31.

    CAS  Google Scholar 

  35. 35

    Beketova, N.A., Kodentsova, V.M., Vrzhesinskaya, O.A., et al., Provision of vitamins of residents of rural settlements of the Russian Arctic, Vop-r. Pitan., 2017, vol. 86, no. 3, p. 83.

    CAS  Google Scholar 

  36. 36

    Malyavskaya, S.I., Zakharova, I.N., Kostrova, G.N., et al., Provision with vitamin D of different-age population living in Arkhangelsk, Vopr. Sovrem. Pediatr., 2015, vol. 14, no. 6, p. 681.

    Article  Google Scholar 

  37. 37

    Baturin, A.K., Sorokina, E.Yu., Vrzhesinskaya, O.A., et al., The relationship of the genetic polymorphism rs2228570 of the VDR gene with vitamin D provision in the inhabitants of the Russian Arctic, Vopr. Pitan., 2017, vol. 86, no. 4, p. 77.

    CAS  PubMed  Google Scholar 

  38. 38

    Nikitinskaya, O.A. and Toroptsova, N.V., Calcium and vitamin D: analysis of possible positive and negative side effects due to their application, Russ. Med. Zh., 2011, vol. 19, no. 10, p. 651.

    Google Scholar 

  39. 39

    Viskari, H., Kondrashova, A., Koskela, P., et al., Circulating vitamin D concentrations in two neighboring populations with markedly different incidence of type I diabetes, Diabetes Care, 2006, vol. 29, no. 6, p. 1458.

    Article  Google Scholar 

  40. 40

    Bakhtiyarova, S., Lesnyak, O., Kyznetsova, N., et al., Vitamin D status among patients with hip fracture and elderly control subjects in Yekaterinburg, Russia, Osteoporosis Int., 2006, vol. 17, no. 3, p. 441.

    CAS  Article  Google Scholar 

  41. 41

    Kozlov, A.I., Vershubskaya, G.G., Kozlova, M.A., and Ryzhaenkov, V.G., The influence of the “traditional” and “westernized” distribution of the products of the “arctic cuisine” on the nutritional status of indigenous northerners, Etnogr. Obozr., 2017, no. 6, p. 146.

  42. 42

    Johnson-Down, L. and Egeland, G.M., Adequate nutrient intakes are associated with traditional food consumption in Nunavut Inuit children aged 3–5 years, J. Nutr., 2010, vol. 140, no. 7, p. 13116.

    Article  Google Scholar 

  43. 43

    Weiler, H.A., Leslie, W.D., Krahn, J., et al., Canadian Aboriginal women have a higher prevalence of vitamin D deficiency than non-Aboriginal women despite similar dietary vitamin D intakes, J. Nutr., 2007, vol. 137, no. 2, p. 461.

    CAS  Article  Google Scholar 

  44. 44

    Brustad, M., Sandanger, T., Wilsgaard, T., et al., Change in plasma levels of vitamin D after consumption of cod-liver and fresh cod-liver oil as part of the traditional north Norwegian fish dish “Molje,” Int. J. Circumpolar Health, 2003, vol. 62, no. 1, p. 40.

    Article  Google Scholar 

  45. 45

    Murashko, O.A. and Dallmann, V.K., Transformations of traditional lifestyle and nutrition of the indigenous people of the Nenets Autonomous Okrug, Vestn. Mosk. Univ., Ser. 23: Antropol., 2011, no. 4, p. 2.

  46. 46

    Wiklund, E. and Johansson, L., Water-holding capacity, color stability and sensory characteristics in meat (M. longissimus dorsi) from reindeer fed two different feeds, Rangifer, 2011, vol. 31, no. 1, p. 49.

    Article  Google Scholar 

  47. 47

    Kuhnlein, H.V., Barthet, V. Farren, A., et al., Vitamins A, D, and E in Canadian Arctic traditional food and adult diets, J. Food Compos. Anal., 2006, vol. 19, nos. 6–7, p. 495.

    CAS  Article  Google Scholar 

  48. 48

    Göring, H., Vitamin D in nature: a product of synthesis and/or degradation of cell membrane components, Biochemistry (Moscow), 2018, vol. 83, no. 11, p. 1350.

    PubMed  Google Scholar 

  49. 49

    Bjorn, L.O. and Wang, T., Vitamin D in an ecological context, Int. J. Circumpolar Health, 2000, vol. 59, no. 1, p. 26.

    CAS  PubMed  Google Scholar 

  50. 50

    Wang, T., Bengtsson, G., Karnefelt, I., and Bjorn, L.O., Provitamins and vitamins D2 and D3 in Cladina spp. over a latitudinal gradient: possible correlation with UV levels, J. Photochem. Photobiol., B, 2001, vol. 62, nos. 1–2, p. 118.

    CAS  Article  Google Scholar 

  51. 51

    Bjorn, L.O., Vitamin D: Photobiological and ecological aspects, in Photobiology: The Science of Light and Life, New York: Springer-Verlag, 2008, 2nd ed.

    Google Scholar 

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The study was performed at the Institute and Museum of Anthropology of Moscow State University (Moscow) in the framework of research “Anthropology of Eurasian Populations (Biological Aspects)” (project no. AAAA-A19-119013090163-2). The study was also partially supported by the Russian Foundation for Basic Research (project no. 18-09-00487).

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Correspondence to A. I. Kozlov.

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The authors report no conflicts of interest related to the implementation of the research and publication of its results. This article does not contain any studies involving animals or human participants performed by any of the authors.

Contribution to the study. The authors made an equal contribution to the collection of materials, their treatment during the study and the creation of the text.

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Translated by M. Batrukova

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Kozlov, A.I., Vershubsky, G.G. Systematic Review on 25-HydroxyvitaminD Levels in Various Populations of the Russian North. Hum Physiol 45, 565–575 (2019).

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  • vitamin D
  • 25-hydroxyvitamin D
  • 25(OH)D
  • vitamin D status
  • Arctic
  • indigenous population
  • nutrition
  • natural light
  • latitude