Skip to main content
SpringerLink
Log in

Dynamics of Lipid Metabolism in Volunteers during Short-Term Isolation in a Hermetic Chamber

  • Published:
Human Physiology Aims and scope Submit manuscript

Abstract

In this study we have examined the crew of the SIRIUS 17 international experiment with a 17-day isolation in a hermetic chamber. The experiment was conducted at the experimental facilities of the Institute of Biomedical Problems, Russian Academy of Sciences. The crew consisted of six people of both sexes aged 27 to 43 years. We measured the serum level of total cholesterol, high-density lipoprotein cholesterol (HDL), apolipoproteins A1 and B, phospholipids, triglycerides, nonesterified (free) fatty acids, and β-hydroxybutyrate. Then we calculated the concentrations of low-density lipoprotein cholesterol (LDL) and very-low-density lipoprotein cholesterol (VLDL) and the values of atherogenic index (IA), ApoB/ApoA1 and phospholipids/cholesterol (PL/CHO) ratios. It was found that the “basic” parameters of cholesterol metabolism (cholesterol, HDL and LDL cholesterol, IA, the ratio of FL/CHO) were almost constant during the experiment, while the parameters indicative of the changes in the lipoprotein spectrum were changing, which reflects atherogenesis. The content of VLDL cholesterol, triglycerides, and ApoB was increasing, as did the value of the ApoB/ApoA1 index. Thus, even a short-term effect of the factors of hermetic chamber leads to the initial shifts in lipid metabolism, which indicate the activation of atherogenesis processes. Our findings show that further studies are needed to investigate the changes in lipid metabolism in experiments with longer periods of isolation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. Ushakov, A.S. and Popova, I.A., Metabolism, in Chelovek v kosmicheskom polete (A Man in Space Flight), Moscow: Nauka, 1997, vol. 3, book 1, ch. 8, p. 328.

  2. Ade, C.J., Broxterman, R.M., and Barstow, T.J., V˙O2max and microgravity exposure: convective versus diffusive O(2) transport, Med. Sci. Sports Exercise, 2015, vol. 47, no. 7, p. 1351.

    Article  Google Scholar 

  3. Hoffmann, U., Moore, A.D., Jr., Koschate, J., et al., V˙O2 and HR kinetics before and after international space station missions, Eur. J. Appl. Physiol., 2016, vol. 116, no. 3, p. 503.

    Article  CAS  Google Scholar 

  4. Baranov, V.M., Gazoenergoobmen cheloveka v kosmicheskom polete i model’nykh issledovaniyakh (Human Gaseous Energy Exchange in Space Flight and Model Studies), Moscow: Nauka, 1993.

  5. Ade, C.J., Broxterman, R.M., Moore, A.D., et al., Decreases in maximal oxygen uptake following long-duration spaceflight: role of convective and diffusive O2 transport mechanisms, J. Appl. Physiol., 2017, vol. 122, no. 4, p. 968.

    Article  CAS  Google Scholar 

  6. Grigor’ev, A.I., Popova, I.A., and Kaplanskii, A.S., Minimum functions of regulatory systems and metabolism in weightlessness, Aviakosm. Ekol. Med., 1993, vol. 27, nos. 5–6, p. 4.

    Google Scholar 

  7. Popova, I.A., Vetrova, E.G., Zaitseva, L.B., et al., Metabolism in cosmonauts: results of blood biochemistry studies in crewmembers of 7 prime missions to the orbital “Mir” station, Physiologist, 1992, vol. 35, no. 1, p. S240.

    CAS  PubMed  Google Scholar 

  8. Panin, L.E., Lipoprotein metabolism and atherosclerosis, Byull. Sib. Otd., Ross. Akad. Med. Nauk, 2006, no. 2, p. 15.

  9. Markin, A., Strogonova, L., Balashov, O., et al., The dynamics of blood biochemical parameters in cosmonauts during long-term space flights, Acta Astronaut., 1998, vol. 42, nos. 1–8, p. 247.

  10. Nichiporuk, I.A. and Morukov, B.V., Analysis of biochemical characteristics during long-term space flights on borad the International Space Station, in Mezhdunarodnaya kosmicheskaya stantsiya. Rossiiskii segment. Kosmicheskaya biologiya i meditsina (International Space Station: Russian Segment: Space Biology and Medicine), Voronezh: Nauchnaya Kniga, 2011, vol. 2, p. 228.

  11. Ushakov, I.B., Bryleva, M.S., Voronkov, Y.I., et al., A cohort mortality study among soviet and Russian cosmonauts, 1961–2014, Aerospace Med. Hum. Perform., 2017, vol. 88, no. 12, p. 1060.

    Article  Google Scholar 

  12. Stuster, J., Analogue prototypes for Lunar and Mars exploration, Aviat. Space Environ. Med., 2005, vol. 76, no. 6, p. B78.

    PubMed  Google Scholar 

  13. Markin, A.A., Zhuravlev, O.A., Morukov, B.V., et al., Homeostatic reactions of the human organism exposed to conditions of 105-day isolation, Aviakosm. Ekol. Med., 2010, vol. 44, no. 4, p. 31.

    Google Scholar 

  14. Walldius, G., Jungner, I., Aastveit, A.H., et al., The Apo B/Apo A-I ratio is better than the cholesterol ratios to estimate the balance between plasma proatherogenic and antiatherogenic lipoproteins and to predict coronary risk, Clin. Chem. Lab. Med., 2004, vol. 42, no. 12, p. 1355.

    Article  CAS  Google Scholar 

  15. Zivanovic, Z., Divjak, I., Jovicevic, M., et al., Association between apolipoproteins AI and B and ultrasound indicators of carotid atherosclerosis, Curr. Vasc. Pharmacol., 2018, vol. 16, no. 4, p. 376.

    Article  CAS  Google Scholar 

  16. Steffen, B.T., Guan, W., Remaley, A.T., et al., Apolipoprotein B is associated with carotid atherosclerosis progression independent of individual cholesterol measures in a 9-year prospective study of multi-ethnic study of atherosclerosis participants, J. Clin. Lipidol., 2017, vol. 11, no. 5, p. 1181.

    Article  Google Scholar 

  17. Efremenko, Yu.R., Koroleva, E.F., and Gorshkova, T.N., Indicators of lipid metabolism and free radical oxidation with metabolic syndrome, Vestn. Nizhegorodsk. Univ. im. N.I. Lobachevskogo, 2011, no. 2, p. 183.

  18. Vel’kov, V.V., Prediktory. Novye vozmozhnosti dlya diagnostiki potentsial’no fatal’nykh patologii i otsenki riskov ikh oslozhnenii (Predictors: New Opportunities for Diagnostics of Potentially Fatal Pathologies and Risk Evaluation of Their Complications), Moscow: Lomonosoff Print, 2009.

  19. Markina, E.A., Il’chenko, E.V., Kuzichkin, D.S., et al., Indicators of cholesterol metabolism in tested people during short-term isolation in the containment, Mezhdunar. Nauchno-Issled. Zh., 2018, no. 4, p. 77.

  20. Heil, W., Koberstein, R., and Zawta, B., Reference Ranges for Adults and Children: Pre-Analytical Considerations, Mannheim: Boehringer, 1997.

    Google Scholar 

  21. Kamyshnikov, V.S., Spravochnik po kliniko-biokhimicheskim issledovaniyam i laboratornoi diagnostike (Guide for Clinical Biochemical Studies and Laboratory Diagnostics), Moscow: MEDpress-Inform, 2009.

  22. Mukhamedieva, L.N., Markina, E.A., Zhuravleva, O.A., et al., Cholesterol metabolism in men and women in a long-term simulated space flight, Mezhdunar. Nauchno-Issled. Zh., 2018, no. 1, p. 61.

  23. Cooke, A.L., Morris, J., Melchior, J.T., et al., A thumbwheel mechanism for APOA1 activation of LCAT activity in HDL, J. Lipid Res., 2018, vol. 59, no. 7, p. 1244.

    Article  CAS  Google Scholar 

  24. Song, X., Tian, S.P., Ju, H.Y., et al., Predictive value of apolipoprotein for coronary atherosclerosis in asymptomatic non-diabetic population, Zhongguo Yi Xue Ke Xue Yuan Xue Bao, 2015, vol. 37, no. 1, p. 55.

    CAS  PubMed  Google Scholar 

  25. Kishkun, A.A., Rukovodstvo po laboratornym metodam diagnostiki (Manual on Laboratory Diagnostics), Moscow: GEOTAR-Media, 2014.

Download references

Funding

The study was supported by the Russian Academy of Sciences (Topic no. 65.1) and Contract no. t-73089 of October 2, 2017, with Wylelaboratories (United States)).

Author information

Authors and Affiliations

  1. Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia

    E. A. Markina, O. A. Zhuravleva, D. S. Kuzichkin, L. N. Mukhamedieva, A. A. Markin, L. V. Vostrikova, I. V. Zabolotskaya & V. I. Loginov

Authors
  1. E. A. Markina
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. O. A. Zhuravleva
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. S. Kuzichkin
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. L. N. Mukhamedieva
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. A. Markin
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. L. V. Vostrikova
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. I. V. Zabolotskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. V. I. Loginov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. A. Markin.

Ethics declarations

Conflict of interests. The authors declare that they have no conflict of interest.

Statement of compliance with standards of research involving humans as subjects. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional Committee for Biomedical Ethics of the Institute of Biomedical Problems of the Russian Academy of Sciences (Moscow) and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants involved in the study.

Additional information

Translated by E.V. Makeeva

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Markina, E.A., Zhuravleva, O.A., Kuzichkin, D.S. et al. Dynamics of Lipid Metabolism in Volunteers during Short-Term Isolation in a Hermetic Chamber. Hum Physiol 45, 421–425 (2019). https://doi.org/10.1134/S036211971904011X

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S036211971904011X

Keywords:

Search

Navigation