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Estimation of Short- and Long-Term Postural Effects Used for Lunar Gravity Simulation on Human Tracheal Forced Expiratory Noise Time

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Abstract

The short- and long-term postural effects on the forced expiratory tracheal noise time were studied in a sample of 12 subjects. In contrast to the spirometric parameters, the tracheal forced expiratory noise time does not respond to a short-term change in the body posture from sitting and standing positions to the lying position, as well as to 14-day-long orthostatic hypokinesia in a lying position with a body angle of +9.6°. However, significant multidirectional individual dynamics of the tracheal forced expiratory noise time was observed in all subjects during long-term orthostatic hypokinesia, whereas the spirometric parameters had a dominant growth response. It is assumed that the estimation of the forced expiratory tracheal noise time during long-term orthostatic hypokinesia in lunar gravity simulation may provide useful data in addition to spirometry when assessing the individual lung function dynamics. The dynamics of acoustic parameters, as well as spirometric parameters, during long-term postural effects can be considered as adaptive changes.

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ACKNOWLEDGMENTS

We are grateful to the subjects who participated in the study as well as to A. Shpakov, A. Tagil’tsev, and S. Shubin for assistance in preparing the experiment.

Funding

The model of the impact of lunar gravity on the human respiratory system was studied at the Institute of Aerospace Medicine under the State Program of the Federal Medical and Biological Agency of the Russian Federation (project Selena-T).

The acoustic part of the study was supported in part by the R&D project no. 0271-2019-0010 under the Basic Research Program for State Academies of Sciences for 2019–2021 of the Il’ichev Pacific Oceanological Institute, Far Eastern Branch, Russian Academy of Sciences (Vladivostok).

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Authors and Affiliations

  1. Department of Acoustic Tomography, Il’ichev Pacific Oceanological Institute, Far Eastern Branch, Russian Academy of Sciences, Vladivostok, Russia

    V. V. Malaeva, I. A. Pochekutova, V. I. Korenbaum, A. E. Kostiv, S. N. Shin & M. A. Safronova

  2. Research Institute for Space Medicine, Federal Biomedical Agency of Russia, Federal Research Clinical Center, Moscow, Russia

    V. P. Katuntsev & V. M. Baranov

Authors
  1. V. V. Malaeva
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  2. I. A. Pochekutova
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  3. V. I. Korenbaum
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  4. A. E. Kostiv
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  5. S. N. Shin
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  6. M. A. Safronova
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  7. V. P. Katuntsev
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  8. V. M. Baranov
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Correspondence to V. V. Malaeva.

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Conflict of interest. The authors declare no explicit and potential conflicts of interest associated with the publication of this article.

Statement of compliance with standards of research involving humans as subjects. All studies were conducted in accordance with the principles of biomedical ethics set out in the 1964 Declaration of Helsinki and its later amendments and approved by the local bioethics committee of the Federal Scientific Clinical Center for Specialized Medical Care and Medical Technology of the Federal Medical and Biological Agency of the Russian Federation (Moscow).

Informed consent. Each study participant provided a signed voluntary written informed consent for the non-invasive study after clarifying any potential risks and benefits as well as the nature of the forthcoming investigations.

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Translated by M. Batrukova

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Malaeva, V.V., Pochekutova, I.A., Korenbaum, V.I. et al. Estimation of Short- and Long-Term Postural Effects Used for Lunar Gravity Simulation on Human Tracheal Forced Expiratory Noise Time. Hum Physiol 45, 412–420 (2019). https://doi.org/10.1134/S0362119719030095

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  • DOI: https://doi.org/10.1134/S0362119719030095

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