Abstract
Peripheral hemodynamics was studied in the upper extremities of human subjects during a 5-day exposure in microgravity modeled by “dry” immersion (DI). The object of investigation was skin adjacent to the nail bed of the fourth finger and forearm skin. Microcirculation was measured using laser Doppler flowmetry (LDF) and computer capillaroscopy (CCS). In addition, peripheral hemodynamics was assessed in subjects donned in a Penguin axial-loading suit (PLS). The subjects were divided into two groups: with (G-2) and without (G-1) PLS. The results are the following: PLS leveled down all changes in the microcirculatory bloodstream (MCB) of the upper extremities. By the end of DI, some subjects in G-1 were found to have a more intensive tissue perfusion and increased number of capillaries, and exaggerated activity of passive mechanism of blood flow modulation Ас (one-way ANOVA, p < 0.05).
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REFERENCES
Gazenko, O.G., Shulzhenko, E.B., Turchaninova, V.F., et al., Central and regional hemodynamics in space flights, Acta Astronaut., 1988, vol. 17, no. 2, pp. 173–179.
Fomina, G.A., Kotovskaya, A.R., Pochuev, V.I., and Zhernavkov, A.F., Mechanisms of changes in human hemodynamics under the conditions of microgravity and prognosis of postflight orthostatic stability, Hum. Physiol., 2008, vol. 34, no. 3, pp. 343–347.
Fomina, G.A., Kotovskaya, A.R., and Temnova, E.V., Dynamics of the human cardiovascular responses in different periods of long-term exposure in weightlessness, Aviakosm. Ekol. Med., 2009, vol. 43, no. 3, pp. 11–16.
Zhu, H., Wang, H.Q., and Liu, Z.Q., Effects of real and simulated weightlessness on the cardiac and peripheral vascular functions of humans: a review, Int. J. Occup. Med. Environ. Health, 2015, vol. 28, no. 5, pp. 793–802.
Hughson, R.L., Shoemaker, J.K., Blaber, A.P., et al., Cardiovascular regulation during long-duration spaceflights to the International Space Station, J. Appl. Physiol., 2012, vol. 112, no. 5, pp. 719–727.
Schrage, W.G., Woodman, C.R., and Laughlin, M.H., Hindlimb unweighting alters endothelium-dependent vasodilation and ecNOS expression in soleus arterioles, J. Appl. Physiol., 2000, vol. 89, no. 4, pp. 1483–1490.
Stout, M.S., Watenpaugh, D.E., Breit, G.A., et al., Simulated microgravity increases cutaneous blood flow in the head and leg of humans, Aviat. Space Environ. Med., 1995, vol. 66, no. 9, pp. 872–875.
Kvandal, P., Landsverk, S.A., Bernjak, A., et al., Low-frequency oscillations of the laser Doppler perfusion signal in human skin, Microvasc. Res., 2006, vol. 72, no. 3, pp. 120–127.
Kvernmo, H.D., Stefanovska, A., Bracic, M., et al., Spectral analysis of the laser Doppler perfusion signal in human skin before and after exercise, Microvasc. Res., 1998, vol. 56, no. 3, pp. 173–182.
Fedorovich, A.A., Rodnenkov, O.V., Ageeva, N.V., et al., Microcirculatory blood flow parameters in human skin under conditions of prolonged heat stress (model experiment), Kardiol. Vestn., 2013, vol. 8, no. 1, pp. 7–17.
Fedorovich, A.A., Non-invasive evaluation of vaso-motor and metabolic functions of microvascular endothelium in human skin, Microvasc. Res., 2012, vol. 84, no. 1, pp. 86–93.
Shul’zhenko, E.B. and Vil-Vil’yams, I.F., The possible long-term water immersion performed by dry immersion method, Kosm. Biol. Aviakosm. Med., 1976, vol. 10, pp. 82–84.
Navasiolava, N.M., Custaud, M.-A., Tomilovskaya, E.S., et al., Long-term dry immersion: review and prospects, Eur. J. of Appl. Phycol., 2011, vol. 111, no. 7, pp. 1235–1260.
Figueiras, E., Campos, R., Semedo, S., et al., A new laser Doppler flowmeter prototype for depth dependent monitoring of skin microcirculation, Rev. Sci. Instrum., 2012, vol. 83, no. 3, pp. 10.
Smits, G.J., Roman, R.J., and Lombard, J.H., Evaluation of laser-Doppler flowmetry as a measure of tissue blood flow, J. Appl. Physiol., 1986, vol. 61, no. 2, pp. 666–672.
Nosovskii, A.M., Development of multidimensional scaling for biomedical research, Aviakosm. Ekol. Med., 2002, vol. 36, no. 3, pp. 62–66.
Navasiolava, N.M., Dignat-George, F., Sabatier, F., et al., Enforced physical inactivity increases endothelial microparticle levels in healthy volunteers, Am. J. Physiol. Heart Circ. Physiol., 2010, vol. 299, no. 2, pp. H248–H256.
Zhang, L.-F., Region-specific vascular remodeling and its prevention by artificial gravity in weightless environment, Eur. J. Appl. Physiol., 2013, vol. 113, no. 12, pp. 2873–2895.
Noskov, V.B., Nichiporuk, I.A., Vasil’eva, G.Yu., and Smirnov, Yu.I., Human body composition during extended stay in microgravity, Aviakosm. Ekol. Med., 2015, vol. 49, no. 1, pp. 19–25.
ACKNOWLEDGMENTS
This study was supported by the Russian Science Foundation, project no. 14-25-00167.
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Translated by E. Sherstyuk
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Suvorov, A.V., Pamova, A.P. & Fedorovich, A.A. Specifics of Microcirculation under the Conditions of “Dry” Immersion. Hum Physiol 44, 794–798 (2018). https://doi.org/10.1134/S0362119718070162
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DOI: https://doi.org/10.1134/S0362119718070162