Skip to main content
SpringerLink
Log in

Effect of Three-minute Cold Exposure in Cryosauna at –70°C on the Human Cellular Immune System

  • Published:
Human Physiology Aims and scope Submit manuscript

Abstract

Cell components of the adaptive and innate immunity were investigated in essentially healthy volunteers aged 27 to 34 years. Peripheral blood was analyzed for absolute and relative counts of lymphocyte phenotypes CD3+, CD3+CD4+, CD3+CD8+, CD19+, CD3–CD16+CD56+, CD3+CD16+CD56+, CD3+CD25+, CD45RA+, CD4+CD45RA+, and monocytes and granulocytes expressing pattern recognition receptors of the Toll-like family (TLR2, TLR4, TLR6) on the cellular membrane. A single cold exposure at –70°С was found to affect cell factors of the human immune system dramatically. Very low temperatures produce different changes in adaptive and congenital components of immunity representing a complex process triggered by the stress-reaction to a short stay in air cryosauna.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Fig. 2.

Similar content being viewed by others

REFERENCES

  1. Solonin, Yu.G. and Boiko, E.R., Medical and physiological aspects of vital activity in Arctic, Arktika: Ekol. Ekon., 2015, no. 1 (17), pp. 70–75.

  2. Agbalyan, E.V., Klimenko, O.A., Buyak, M.A., et al., Basic predictors of the development and further progression of coronary heart disease among migrants of the Arctic, Usp. Sovrem. Estestvozn., 2014, no. 9, pp. 8–10.

  3. Hausswirth, C., Schaal, K., Le Meur, Y., et al., Parasympathetic activity and blood catecholamine responses following a single partial-body cryostimulation and a whole-body cryostimulation, PLoS One, 2013, vol. 8, no. 8.

  4. Launay, J.C. and Savourey, G., Cold adaptations, Ind. Health, 2009, vol. 47, no. 3, pp. 221–227.

    Article  PubMed  Google Scholar 

  5. Selfe, J., Alexander, J., Costello, J.T., et al., The effect of three different (–135°C) whole body cryotherapy exposure durations on Elite Rugby League Players, PLoS One, 2014, vol. 9, no. 1, p. e86420.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  6. Brazaitis, M., Eimantas, N., Daniuseviciute, L., et al., Two strategies for response to 14°C cold-water immersion: Is there a difference in the response of motor, cognitive, immune and stress markers? PLoS One, 2014, vol. 9, no. 9.

  7. Lubkowska, A., Szyguła, Z., Klimek, A.J., et al., Do sessions of cryostimulation have influence on white blood cell count, level of IL-6 and total oxidative and antioxidative status in healthy men? Eur. J. Appl. Physiol., 2010, vol. 109, no. (1):67-72.

  8. Lubkowska, A., Szyguła, Z., Chlubek, D., et al., The effect of prolonged whole-body cryostimulation treatment with different amounts of sessions on chosen pro- and anti-inflammatory cytokines levels in healthy men, Scand. J. Clin. Lab. Invest., 2011, vol. 71, no. 5, pp. 419–425.

    Article  PubMed  CAS  Google Scholar 

  9. Jansky, L., Pospisilova, D., Honzova, S., et al., Immune system of cold-exposed and cold- adapted humans, Eur. J. Appl. Physiol. Occup. Physiol., 1996, vol. 72, pp. 445–450.

    Article  PubMed  CAS  Google Scholar 

  10. Takamoto, T., Hori, Y., Koga, Y., et al., Norepinephrine inhibits human natural killer cell activity in vitro, Int. J. Neurosci., 1991, vol. 58, pp. 127–131.

    Article  PubMed  CAS  Google Scholar 

  11. McFarlin, B.K. and Mitchell, J.B., Exercise in hot and cold environments: differential effects on leukocyte number and NK cell activity, Aviat. Space Environ. Med., 2003, vol. 74, pp. 1231–1236.

    PubMed  Google Scholar 

  12. Banfi, G., Melegati, G., Barassi, A., et al., Effects of whole-body cryotherapy on serum mediators of inflammation and serum muscle enzymes in athletes, J. Therm. Biol., 2009, vol. 34, pp. 55–59.

    Article  CAS  Google Scholar 

  13. Brazaitis, M., Eimantas, N., Daniuseviciute, L., et al., Two strategies for the acute response to cold exposure but one strategy for the response to heat stress, Int. J. Hyperthermia, 2015, vol. 31, no. 4, pp. 325–351.

    Article  PubMed  CAS  Google Scholar 

  14. Dopp, J.M., Miller, G.E., Myers, H.F., et al., Increased natural killer-cell mobilization and cytotoxicity during marital conflict, Brain Behav. Immunol., 2000, vol. 14, no. 1, pp. 10–26.

    Article  CAS  Google Scholar 

  15. Wong, J., Murthy, A., and Patterson, M., Beta-adrenergic receptors (βAR): role in modulating the host immune response, in Seminars in Anesthesia, Perioperative Medicine and Pain, Amsterdam: Elsevier, 2007, vol. 26, pp. 10–16.

    Google Scholar 

  16. Steensberg, A., Fischer, C.P., Keller, C., et al., IL-6 enhances plasma IL-1ra, IL-10 and cortisol in humans, Am. J. Endocrinol. Metab., 2003, vol. 285, pp. 433–437.

    Article  Google Scholar 

Download references

ACKNOWLEDGMENTS

The study was carried out in the framework of the Basic Research Program of the Institute of Biomedical Problems of the Russian Academy of Sciences.

Author information

Authors and Affiliations

  1. Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia

    S. A. Ponomarev, A. V. Muranova, S. A. Kalinin, E. N. Antropova, M. P. Rykova, M. M. Saltykova & O. I. Orlov

Authors
  1. S. A. Ponomarev
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. V. Muranova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. A. Kalinin
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. E. N. Antropova
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. P. Rykova
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. M. M. Saltykova
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. O. I. Orlov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to S. A. Ponomarev.

Additional information

Translated by I. Matiulko

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ponomarev, S.A., Muranova, A.V., Kalinin, S.A. et al. Effect of Three-minute Cold Exposure in Cryosauna at –70°C on the Human Cellular Immune System. Hum Physiol 44, 810–814 (2018). https://doi.org/10.1134/S0362119718070137

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0362119718070137

Keywords:

Search

Navigation