Skip to main content
SpringerLink
Log in

Features of Human Metabolic Reactions under Extreme Cold Exposure

  • Published:
Human Physiology Aims and scope Submit manuscript

An Erratum to this article was published on 01 July 2018

This article has been updated

Abstract

We measured 45 biochemical indices of blood serum samples in six volunteers aged 23–35 years before and after 3-min exposure to air cryosauna at a temperature of–70°С. We observed an increase in the activity of glutamate dehydrogenase (by a factor of 3.4), aspartate aminotransferase (by 46%), lipase (52%), lactate dehydrogenase (16%), cholinesterase (18%), leucin aminopeptidase (12%), and prostatic acid phosphatase (45%). Moreover, we observed an increase in the level of free fatty acids (by a factor of 2.8), HDLcholesterol (by 10%), creatinine (21%), glucose and ß-hydroxybutirate (11%), high-sensitivity C-reactive protein (12%), potassium (14%), and chlorides (7%). In contrast, atherogenic index values decreased by 14% compared with background level. Most of changes in biochemical blood parameters mentioned above remained almost constant within 20, 60, and 180 min after 3 min of cryosauna; the values did not reach their initial levels. It is concluded that urgent adaptation of human body to low temperatures is associated with increased intensification of reactions in the respiratory chain of mitochondria, an increase in the rate of metabolic reactions due to the elevated production of energy substances resulting from activation of lipolysis and glycolysis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Change history

  • 14 August 2018

    Reference no. 5 should read as follows:

References

  1. Pastukhov, Yu.F., Maksimov, A.L., and Khaskin, V.V., Adaptatsiya k kholodu i usloviyam Subarktiki: problemy termofiziologii (Adaptation to the Cold and Subarctic Conditions: Problems of Thermophysiology), Magadan: Sev.-Vost. Nauch. Tsentr, Dal’nevost. Otd., Ross. Akad. Nauk, 2003, vol. 1.

  2. Venditti, P., De Rosa, R., Caldarone, G., and Di Meo, S., Functional and biochemical characteristics of mitochondrial fractions from rat liver in cold-induced oxidative stress, Cell Mol. Life Sci., 2004, vol. 61, no. 24, p. 3104.

    Article  PubMed  CAS  Google Scholar 

  3. Maeda, T., Fukushima, T., Ishibashi, K., and Higuchi, S., Involvement of basal metabolic rate in determination of type of cold tolerance, J. Physiol. Anthropol., 2007, vol. 26, no. 3, p. 415.

    Article  PubMed  Google Scholar 

  4. Wang, J.-J. and Chen, C.-C., Study of the effect of short-time cold stress on heart rate variability, Proc. 13th Int. Conf. on Biomedical Engineering, New York: Springer-Verlag, 2009, vol. 23, p. 490.

    Google Scholar 

  5. Lutsenko, D.G., Shilo, A.V., Marchenko, L.N., et al., Specific regulation of heart rhythm under different types of cold adaptation in rats, Probl. Kriobiol. Kriomed., 2013, vol. 23, no. 2, p. 105.

    Google Scholar 

  6. Lunt, H.C., Barwood, M.J., Corbett, J., and Tipton, M.J., Crossadaptation: habituation to short repeated cold-water immersions affects the response to acute hypoxia in humans, J. Physiol., 2010, vol. 588, no. 18, p. 3605.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  7. Kamyshnikov, V.S., Spravochnik po klinikobiokhimicheskim issledovaniyam i laboratornoi diagnostike (Guidebook on Clinical Chemistry Tests and Laboratory Diagnosis), Moscow: MEDpress-Inform, 2009.

    Google Scholar 

  8. Tret’yak, L.N., Obrabotka rezul’tatov nablyudenii. Uchebnoe posobie (Experimental Data Processing: Manual), Orenburg: Orenb. Gos. Univ., 2004.

    Google Scholar 

  9. Kulikov, V.Yu., Semenyuk, A.V., and Kolesnikova, L.I., Perekisnoe okislenie lipidov i kholodovyi faktor (Lipid Peroxidation and Cold Factor), Novosibirsk: Nauka, 1988.

    Google Scholar 

  10. Bignucolo, A., Appanna, V.P., Thomas, S.C., et al., Hydrogen peroxide stress provokes a metabolic reprogramming in Pseudomonas fluorescens: enhanced production of pyruvate, J. Biotechnol., 2013, vol. 167, no. 3, p. 309.

    Article  PubMed  CAS  Google Scholar 

  11. Evdokimova, O.V. and Gorodetskaya, I.V., The influence of experimental hypothyroidism and low doses of L-thyroxin on the activity of aminotransferases and gamma-glutamyltransferase in blood affected by different stresses, Vestn. Vitebsk. Gos. Med. Univ., 2013, vol. 12, no. 4, p. 34.

    Google Scholar 

  12. Solov’eva, A.G., Razmakhov, A.M., Luzan, A.S., et al., Mitochondrial lactate dehydrogenase from rats liver after cold stress, Fundam. Issled., 2008, no. 2, p. 56.

    Google Scholar 

  13. Avakyan, A.R., Lazarev, A.I., Prokopenko, L.G., and Uteshev, B.S., Immunomodulative action of the activators of carbohydrate and lipid metabolism in acute cold stress, Eksp. Klin. Farmakol., 2002, vol. 65, no. 3, p. 50.

    CAS  Google Scholar 

  14. Kushnerova, N.F., Sprygin, V.G., Fomenko, S.E., et al., The influence of stress on the lipid and carbohydrate metabolism in the liver: prevention, Gig. Sanit., 2005, no. 5, p. 17.

    Google Scholar 

  15. Zhigulina, V.V., Biochemical response of the organism to stress: literature review, Verkhnevolzhsk. Med. Zh., 2014, vol. 12, no. 4, p. 25.

    Google Scholar 

  16. Vel’kov, V.V., Free fatty acids as a new marker of insulin resistance and ischemia, Dal’nevost. Med. Zh., 2008, no. 4, p. 120.

    Google Scholar 

  17. Higgins, C., Understanding Laboratory Investigations for Nurses and Health Professionals, New York: Wiley, 2007.

    Google Scholar 

  18. Lubkowska, A., Szygula, Z., Klimek, A.J., and Torii, M., Do sessions of cryostimulation have influence on white blood cell count, level of IL6 and total oxidative and antioxidative status in healthy men? Eur. J. Appl. Physiol., 2010, vol. 109, p. 67.

    Article  PubMed  CAS  Google Scholar 

  19. Zarubina, I.V., Ganapol’skii, V.P., Aleksandrov, P.V., and Shabanov, P.D., Metoadaptogenic properties of trekrezan in healthy volunteers after cold exposure, Psikhofarmakol. Biol. Narkol., 2007, vol. 7, no. 1, p. 1459.

    Google Scholar 

  20. Hauton, D., May, S., Sabharwal, R., et al., Coldimpaired cardiac performance in rats is only partially overcome by cold acclimation, J. Exp. Biol., 2011, vol. 214, no. 18, p. 3021.

    Article  PubMed  Google Scholar 

  21. Sayapina, I.Yu. and Tseluiko, I.S., Dynamics of quantitative indicators of Leydig cells in the organism adaptation to low temperatures, Dal’nevost. Med. Zh., 2011, no. 2, p 84.

    Google Scholar 

  22. Postnikova, S.L., Kasatova, T.B., Vereshchagina, G.S., and Malysheva, N.V., Magnesium and cardiovascular diseases, Kardiologiya, 2007, vol. 15, no. 20, p. 1.

    Google Scholar 

  23. Mishchuk, N.E., Hypothermia, Med. Neotlozhnykh Sostoyanii, 2006, no. 4 (5), p. 42.

    Google Scholar 

  24. Postnikov, A.A., Vodno-mineral’nyi obmen (Water-Mineral Metabolism), Moscow: Triada-Farm, 2004.

    Google Scholar 

  25. Prosina, L.A. and Lomteva, N.A., Free radical processes in the tissues of the thyroid and adrenal glands of immature male rats in the early period of cold exposure and their dependence on adaptation to periodic cooling, Estestv. Nauki, 2007, no. 4 (21), p. 73.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia

    O. A. Juravlyova, A. A. Markin, D. S. Kuzichkin, M. M. Saltuikova, V. I. Loginov, I. V. Zabolotskaya & L. V. Vostrikova

Authors
  1. O. A. Juravlyova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. A. Markin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. S. Kuzichkin
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. M. Saltuikova
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. V. I. Loginov
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. I. V. Zabolotskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. L. V. Vostrikova
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. A. Markin.

Additional information

Original Russian Text © O.A. Juravlyova, A.A. Markin, D.S. Kuzichkin, M.M. Saltuikova, V.I. Loginov, I.V. Zabolotskaya, L.V. Vostrikova, 2018, published in Fiziologiya Cheloveka, 2018, Vol. 44, No. 3, pp. 109–115.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Juravlyova, O.A., Markin, A.A., Kuzichkin, D.S. et al. Features of Human Metabolic Reactions under Extreme Cold Exposure. Hum Physiol 44, 330–335 (2018). https://doi.org/10.1134/S0362119718030167

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0362119718030167

Keywords

Search

Navigation