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Functional Geometry of the Left Ventricle in Term Newborns with Different Birth Weights

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Abstract

Ontogenesis is associated with significant changes in the structure and function of the left ventricle (LV). The functional geometry of the LV concerns the dynamic changes in the ventricular shape during contraction and relaxation. The purpose of this study was to evaluate the LV functional geometry in term newborns with normal and low birth weights and to evaluate the heart maturation in newborns as compared with adults. A total of 24 healthy adults, 35 term singleton newborns and 40 term twin newborns were examined using 2D echocardiography. Systolic changes in the LV segmental areas were evaluated, and dynamic changes in the LV shape during the cardiac cycle were specified. The spatial heterogeneity in regional movements of the LV wall was higher and LV shape indexes were more complex than in adults. A negative correlation between the ejection fraction and spatial heterogeneity was found in all groups. No significant dependence was observed between the birth weight and the LV functional geometry characteristics in newborns with normal and low birth weights. The results suggest that regular temporal and spatial coordination of LV wall movements is not completely developed in newborns. No significant dependence was observed between the birth weight and the LV functional geometry characteristics in term newborns.

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REFERENCES

  1. Chumarnaya, T., Solovyova, O., Sukhareva, S., et al., Spatio-temporal heterogeneity of the contraction of the left ventricular wall in norm and at heart ischemia, Ross. Fiziol. Zh. im. I.M. Sechenova, 2008, vol. 94, no. 11, p. 1217.

    Google Scholar 

  2. Markhasin, V., Solovyova, O., Chumarnaya, T., and Sukhareva, S., The problem of myocardial heterogeneity, Ross. Fiziol. Zh. im. I.M. Sechenova, 2009, vol. 95, no. 9, p. 919.

    Google Scholar 

  3. Chumarnaya, T., Alueva, Y.S., Kochmasheva, V., et al., Features of the left ventricular functional geometry in patients with myocardial diseases with varying degrees of systolic dysfunction, Bull. Exp. Biol. Med., 2016, vol. 162, no. 1, p. 30.

    Article  PubMed  CAS  Google Scholar 

  4. Omar, A.M.S., Vallabhajosyula, S., and Sengupta, P.P., Left ventricular twist and torsion: research observations and clinical applications, Circ.: Cardiovasc. Imaging, 2015, vol. 8, no. 6, p. e003029.

    Google Scholar 

  5. Mollova, M., Bersell, K., Walsh, S., et al., Cardiomyocyte proliferation contributes to heart growth in young humans, Proc. Natl. Acad. Sci. U.S.A., 2013, vol. 110, no. 4, p. 1446.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Polin, R.A., Fox, W.W., and Abman, S.H., Fetal and Neonatal Physiology, Philadelphia: WB Saunders, 2011, p. 696.

    Google Scholar 

  7. Tsyvian, P. and Kovtun, O., Intrauterine programming of diseases of children and adults, Usp. Fiziol. Nauk, 2008, vol. 39, no. 1, p. 68.

    CAS  Google Scholar 

  8. Fil’kina, O., Vorob’eva, E., Dolotova, N., et al., Risk factors and algorithm for forecasting of health disorders by the year of life in children born with very low and extremely low body weight, Analiz Riska Zdorov’yu, 2016, vol. 13, no. 1, p. 69.

    Google Scholar 

  9. Lutfullin, I.Ya., Safina, A.I., and Sadykova, Z.R., Contribution of body mass deficit at birth to the risk of subsequent cardiovascular pathology, Vestn. Sovrem. Clin. Med., 2013, vol. 6, no. 1, p. 53.

    Google Scholar 

  10. Antonisamy, B., Vasan, S.K., Geethanjali, F.S., et al., Weight gain and height growth during infancy, childhood, and adolescence as predictors of adult cardiovascular risk, J. Pediatr., 2017, vol. 180, p. 53.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Osmond, C. and Barker, D., Fetal, infant, and childhood growth are predictors of coronary heart disease, diabetes, and hypertension in adult men and women, Environ. Health Perspect., 2000, vol. 108, no. 3, p. 545.

    PubMed  PubMed Central  Google Scholar 

  12. Chumarnaya, T., Solovyova, O., Alueva, Y., et al., Left ventricle functional geometry in cardiac pathology, Comput. Cardiol., 2015, vol. 42, no. 1, p. 353.

    Google Scholar 

  13. Shiota, T., Harada, K., and Takada, G., Left ventricular systolic and diastolic function during early neonatal period using transthoracic echocardiography, Tohoku J. Exp. Med., 2002, vol. 197, no. 3, p. 151.

    Article  PubMed  Google Scholar 

  14. Toyono, M., Assessment of Ventricular-Vascular Function by Echocardiography, New York: Springer-Verlag, 2015, p. 143.

    Book  Google Scholar 

  15. Graham, E. and Bergmann, O., Dating the heart: exploring cardiomyocyte renewal in humans, Physiology, 2017, vol. 32, no. 1, p. 33.

    Article  PubMed  CAS  Google Scholar 

  16. Samsa, L.A., Yang, B., and Liu, J., Embryonic cardiac chamber maturation: trabeculation, conduction, and cardiomyocyte proliferation, Am. J. Med. Genet., 2013, vol. 163, p. 157.

    Article  Google Scholar 

  17. Notomi, Y., Srinath, G., Shiota, T., et al., Maturational and adaptive modulation of left ventricular torsional biomechanics: Doppler tissue imaging observation from infancy to adulthood, Circulation, 2006, vol. 113, no. 21, p. 2534.

    Article  PubMed  Google Scholar 

  18. Watson, T., McCracken, C.E., Slesnick, T., et al., Quantitative assessment of ventricular septal contour for estimation of right ventricular pressure, Echocardiography, 2016, vol. 33, no. 3, p. 444.

    Article  PubMed  Google Scholar 

  19. Moon-Grady, A.J. and Hornberger, L.K., Fetal Myocardial Mechanics, New York: Springer-Verlag, 2014, p. 249.

    Book  Google Scholar 

  20. Jonker, S.S., Louey, S., Giraud, G.D., et al., Timing of cardiomyocyte growth, maturation, and attrition in perinatal sheep, FASEB J., 2015, vol. 29, no. 10, p. 4346.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  21. Eriksson, J.G., Venojärvi, M., and Osmond, C., Prenatal and childhood growth, Chemerin concentrations, and metabolic health in adult life, Int. J. Endocrinol., 2016. http://dx.doi.org/10.1155/2016/3838646

  22. Tyrrell, J., Richmond, R.C., Palmer, T.M., et al., Genetic evidence for causal relationships between maternal obesity-related traits and birth weight, JAMA, J. Am. Med. Assoc., 2016, vol. 315, no. 1, p. 1129.

    Article  CAS  Google Scholar 

  23. Zhang, Z., Kris-Etherton, P.M., and Hartman, T.J., Birth weight and risk factors for cardiovascular disease and type 2 diabetes in US children and adolescents: 10 year results from NHANES, Matern. Child Health J., 2014, vol. 18, no. 6, p. 1423.

    Article  PubMed  Google Scholar 

  24. Lewandowski, A., Augustine, D., Lamata, P., et al., Preterm heart in adult life: cardiovascular magnetic resonance reveals distinct differences in left ventricular mass, geometry, and function, Circulation, 2013, vol. 127, no. 2, p. 197.

    Article  PubMed  Google Scholar 

  25. Minyailova, N.N., Rovda, Yu.I., Shishkova, Yu.N., and Stroeva, V.P., The risk of obesity, hypertension and metabolic syndrome in young age depending on the body weight at birth, Mat’ Ditya Kuzbasse, 2016, vol. 67, p. 45.

    Google Scholar 

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ACKNOWLEDGMENTS

We thank Prof. Yu. M. Vladimiroff for his helpful remarks and critical estimation of the manuscript.

This study was carried out within the framework of the IIF UrB RAS (theme No. АААА-А18-118020590031-8) and supported by RF Government Act #211 of March 16, 2013 (agreement 02.А03.21.0006).

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Authors and Affiliations

  1. Institute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences, Yekaterinburg, Russia

    T. V. Chumarnaya & O. E. Solovyova

  2. Ural Federal University, Yekaterinburg, Russia

    T. V. Chumarnaya & O. E. Solovyova

  3. Ural State Medical University, Yekaterinburg, Russia

    T. V. Chumarnaya, P. B. Tsyvian & O. E. Solovyova

  4. Ural Research Institute of Maternity and Infancy Protection, Yekaterinburg, Russia

    O. A. Kraeva & P. B. Tsyvian

Authors
  1. T. V. Chumarnaya
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  2. O. A. Kraeva
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  3. P. B. Tsyvian
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  4. O. E. Solovyova
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Correspondence to T. V. Chumarnaya.

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Translated by E. Sherstyuk

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Chumarnaya, T.V., Kraeva, O.A., Tsyvian, P.B. et al. Functional Geometry of the Left Ventricle in Term Newborns with Different Birth Weights. Hum Physiol 44, 565–573 (2018). https://doi.org/10.1134/S0362119718030040

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  • DOI: https://doi.org/10.1134/S0362119718030040

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