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Electrophysiological Correlates of Major Depression Disorder with Anxious Distress in Patients of Different Age Groups

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Abstract

The electrophysiological correlates of major depression disorder with anxious distress in patients of different age groups have been investigated. The spectral characteristics of 19-channel background EEG were analyzed and the power spectra recorded with the eyes closed vs. eyes open in 64 patients with anxiety–depressive disorder and in 194 healthy subjects were compared. The subjects were divided into the two age groups: 18–39 and 40–76 years old. The spectral parameters were calculated for 5 main EEG frequency bands: θ (4–8 Hz), α (8–12 Hz), β1 (12–20 Hz), β2 (20–30 Hz), and γ (30–40 Hz). The most statistically significant differences between the groups were found in the α, β, and γ bands. Lower values of spectral power of the α rhythm in occipital areas and the higher values of spectral power of the β and γ rhythms in the frontocentral region were recorded in the group of 18-to-39-year-old patients with the eyes closed. Higher values of spectral power of the β rhythm in the fronto-central region and in the left temporal lobe were recorded in the group of 40-to-76-year-old patients with both the eyes closed and the eyes open. The higher β-activity in the fronto-central regions in both groups of patients may be caused by increased excitability of the cerebral cortex and decreased activity of inhibitory processes. Increased activation of the left temporal lobe in older subjects is probably associated with the severity of anxiety symptoms and may be a distinctive marker of mixed anxiety and depressive disorder. The lower values of α-power revealed only in the group of younger subjects are probably associated with age-related reorganization of EEG in older subjects.

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Authors and Affiliations

  1. Institute of Experimental Medicine, St. Petersburg, 197376, Russia

    T. F. Shamaeva & V. M. Klimenko

  2. Bechtereva Institute of the Human Brain, St. Petersburg, 197376, Russia

    M. V. Pronina & Y. I. Polyakov

  3. Mechnikov Northwestern State Medical University, St. Petersburg, 191144, Russia

    G. Yu. Polyakova

Authors
  1. T. F. Shamaeva
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  2. M. V. Pronina
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  3. G. Yu. Polyakova
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  4. Y. I. Polyakov
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  5. V. M. Klimenko
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Correspondence to T. F. Shamaeva.

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Original Russian Text © T.F. Shamaeva, M.V. Pronina, G.Yu. Polyakova, Y.I. Polyakov, V.M. Klimenko, 2018, published in Fiziologiya Cheloveka, 2018, Vol. 44, No. 1, pp. 5–11.

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Shamaeva, T.F., Pronina, M.V., Polyakova, G.Y. et al. Electrophysiological Correlates of Major Depression Disorder with Anxious Distress in Patients of Different Age Groups. Hum Physiol 44, 1–6 (2018). https://doi.org/10.1134/S0362119718010152

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  • DOI: https://doi.org/10.1134/S0362119718010152

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