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Strategies of adaptation of small arteries in diaphragm and gastrocnemius muscle to aerobic exercise training

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Abstract

Aerobic exercise training is associated with adaptive changes in skeletal muscles and their vascular bed; such changes in individual muscles may vary depending on their characteristics and recruitment. This study was aimed at comparing the effects of eight-week treadmill training on the locomotor and respiratory muscles in rats. The training course increased the aerobic performance in rats, which was evidenced by an increase in maximum O2 consumption and a decrease in the blood lactate concentration in ramp test. The succinate dehydrogenase activity was increased in the red portion of the gastrocnemius muscle, but not in the diaphragm of trained rats. Arterial segments were isolated from feed arteries and studied by wire myography. The relaxation in response to acetylcholine in gastrocnemius arteries in trained animals was higher as compared with controls (due to higher NO production), while contractile responses to noradrenaline (in the presence of propranolol) were not changed. On the contrary, the endothelial function of diaphragm arteries was not affected by training, but contractile responses to activation of α-adrenoceptors were markedly increased. Thus, aerobic training may increase the blood supply rate to both locomotor and respiratory muscles, but the underlying regulatory mechanisms are different. The results obtained allow us to reveal the physiological mechanisms that determine the physical performance of the body under conditions of compromised functioning of the respiratory system.

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References

  1. Popov, D.V., Vinogradova, O.L., and Grigor’ev, A.I., Aerobnaya rabotosposobnost’ cheloveka (Human Aerobic Performance), Moscow: Nauka, 2012.

    Google Scholar 

  2. Segizbaeva, M.O., Timofeev, N.N., Donina, Z.A., et al., Effects of inspiratory muscle training on resistance to fatigue of respiratory muscles during exhaustive exercise, Adv. Exp. Med. Biol., 2015, vol. 840, p. 35.

    Article  CAS  PubMed  Google Scholar 

  3. Burtscher, M., Exercise limitations by the oxygen delivery and utilization systems in aging and disease: Coordinated adaptation and deadaptation of the lung-heart muscle axis–a mini-review, Gerontology, 2013, vol. 59, no. 4, p. 289.

    Article  PubMed  Google Scholar 

  4. Cahalin, L.P. and Arena, R.A., Breathing exercises and inspiratory muscle training in heart failure, Heart Fail. Clin., 2015, vol. 11, no. 1, p. 149.

    Article  PubMed  Google Scholar 

  5. Joyner, M.J. and Casey, D.P., Regulation of increased blood flow (hyperemia) to muscles during exercise: A hierarchy of competing physiological needs, Physiol. Rev., 2015, vol. 95, no. 2, p. 549.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Laughlin, M.H. and Roseguini, B., Mechanisms for exercise training-induced increases in skeletal muscle blood flow capacity: Differences with interval sprint training versus aerobic endurance training, J. Physiol. Pharmacol., 2008, vol. 59, no. 7, p. 71.

    PubMed  PubMed Central  Google Scholar 

  7. Laughlin, M.H., Woodman, C.R., Schrage, W.G., et al., Interval sprint training enhances endothelial function and eNOS content in some arteries that perfuse white gastrocnemius muscle, J. Appl. Physiol., 2004, vol. 96, no. 1, p. 233.

    Article  CAS  PubMed  Google Scholar 

  8. McAllister, R.M., Jasperse, J.L., and Laughlin, M.H., Nonuniform effects of endurance exercise training on vasodilation in rat skeletal muscle, J. Appl. Physiol., 2005, vol. 98, no. 2, p. 753.

    Article  CAS  PubMed  Google Scholar 

  9. Aaker, A. and Laughlin, M.H., Differential adenosine sensitivity of diaphragm and skeletal muscle arterioles, J. Appl. Physiol., 2002, vol. 93, no. 3, p. 848.

    Article  CAS  PubMed  Google Scholar 

  10. Hilton, S.M., Jeffries, M.G., and Vrbová, G., Functional specializations of the vascular bed of soleus, J. Physiol., 1970, vol. 206, no. 3, p. 543.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Donato, A.J., Lesniewski, L.A., and Delp, M.D., Ageing and exercise training alter adrenergic vasomotor responses of rat skeletal muscle arterioles, J. Physiol., 2007, vol. 579, p. 115.

    Article  CAS  PubMed  Google Scholar 

  12. Powers, S.K. and Criswell, D., Adaptive strategies of respiratory muscles in response to endurance exercise, Med. Sci. Sports Exercise, 1996, vol. 28, no. 9, p. 1115.

    Article  CAS  Google Scholar 

  13. Tamaki, N., Effect of endurance training on muscle fiber type composition and capillary supply in rat diaphragm, Eur. J. Appl. Physiol. Occup. Physiol., 1987, vol. 56, no. 2, p. 127.

    Article  CAS  PubMed  Google Scholar 

  14. Borzykh, A.A., Kuzmin, I.V., Borovik, A.S., et al., Changes of rat respiratory and locomotory muscles during aerobic exercise training in continuous and interval regimens, Biophysics, 2012, vol. 57, no. 5, p. 684.

    Article  CAS  Google Scholar 

  15. Poole, D.C., Sexton, W.L., Behnke, B.J., et al., Respiratory muscle blood flows during physiological and chemical hyperpnea in the rat, J. Appl. Physiol., 2000, vol. 88, no. 1, p. 186.

    CAS  PubMed  Google Scholar 

  16. Tarasova, O.S., Kalenchuk, V.U., Borzykh, A.A., et al., A comparative analysis of the vasomotor responses and innervation of small arteries in rat locomotor and respiratory muscles, Biophysics, 2008, vol. 53, no. 6, p. 621.

    Article  Google Scholar 

  17. Bedford, T.G., Tipton, C.M., Wilson, N.C., et al., Maximum oxygen consumption of rats and its changes with various experimental procedures, J. Appl. Physiol., 1979, vol. 47, no. 6, p. 1278.

    CAS  PubMed  Google Scholar 

  18. Carvalho, J.F., Masuda, M.O., and Pompeu, F.A.M.S., Method for diagnosis and control of aerobic training in rats based on lactate threshold, Comp. Biochem. Physiol., Part A: Mol. Integr. Physiol., 2005, vol. 140, no. 4, p. 409.

    Article  Google Scholar 

  19. Armstrong, R.B. and Laughlin, M.H., Exercise blood flow patterns within and among rat muscles after training, Am. J. Physiol., 1984, vol. 246, p. H59.

    CAS  PubMed  Google Scholar 

  20. Borzykh, A.A., Andreev-Andrievskii, A.A., Sharova, A.P., et al., Diaphragm muscle and its feed artery after chronic respiratory airway obstruction in rats, Biophysics, 2010, vol. 55, no. 5, p. 826.

    Article  Google Scholar 

  21. Luginbuhl, A.J., Dudley, G.A., and Staron, R.S., Fiber type changes in rat skeletal muscle after intense interval training, Histochemistry, 1984, vol. 81, no. 1, p. 55.

    Article  CAS  PubMed  Google Scholar 

  22. Suzuki, J., Kobayashi, T., Uruma, T., and Koyama, T., Time-course changes in arteriolar and venular portions of capillary in young treadmill-trained rats, Acta Physiol. Scand., 2001, vol. 171, no. 1, p. 77.

    CAS  PubMed  Google Scholar 

  23. Fregosi, R.F., Sanjak, M., and Paulson, D.J., Endurance training does not affect diaphragm mitochondrial respiration, Respir. Physiol., 1987, vol. 67, no. 2, p. 225.

    Article  CAS  PubMed  Google Scholar 

  24. Segal, S.S., Integration of blood flow control to skeletal muscle: Key role of feed arteries, Acta Physiol. Scand., 2000, vol. 168, no. 4, p. 511.

    Article  CAS  PubMed  Google Scholar 

  25. McAllister, R.M., Newcomer, S.C., and Laughlin, M.H., Vascular nitric oxide: Effects of exercise training in animals, Appl. Physiol., Nutr., Metab., 2008, vol. 33, no. 1, p. 173.

    Article  CAS  Google Scholar 

  26. Whyte, J.J. and Laughlin, M.H., The effects of acute and chronic exercise on the vasculature, Acta Physiol. (Oxford), 2010, vol. 199, no. 4, p. 441.

    Article  CAS  Google Scholar 

  27. van Deel, E.D., Merkus, D., van Haperen, R., et al., Vasomotor control in mice overexpressing human endothelial nitric oxide synthase, Am. J. Physiol.: Heart Circ. Physiol., 2007, vol. 293, no. 2, p. H1144.

    Google Scholar 

  28. Vinogradova, O.L., Popov, D.V., Tarasova, O.S., et al., Ergoreflex: The essence and mechanisms, Hum. Physiol., 2012, vol. 38, no. 7, p. 665.

    Article  Google Scholar 

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Authors and Affiliations

  1. Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia

    A. A. Borzykh, I. V. Kuzmin, A. S. Borovik, O. L. Vinogradova & O. S. Tarasova

  2. Lomonosov State University, Moscow, Russia

    A. A. Andreev-Andrievskiy, V. U. Kalenchuk, S. V. Mochalov, S. V. Buravkov, I. V. Kuzmin & O. S. Tarasova

  3. KhimRar High-Technology Center, Khimki, Moscow oblast, Russia

    S. V. Mochalov

Authors
  1. A. A. Borzykh
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  2. A. A. Andreev-Andrievskiy
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  3. V. U. Kalenchuk
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  4. S. V. Mochalov
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  5. S. V. Buravkov
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  6. I. V. Kuzmin
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  7. A. S. Borovik
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  8. O. L. Vinogradova
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  9. O. S. Tarasova
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Corresponding author

Correspondence to O. S. Tarasova.

Additional information

Original Russian Text © A.A. Borzykh, A.A. Andreev-Andrievskiy, V.U. Kalenchuk, S.V. Mochalov, S.V. Buravkov, I.V. Kuzmin, A.S. Borovik, O.L. Vinogradova, O.S. Tarasova, 2017, published in Fiziologiya Cheloveka, 2017, Vol. 43, No. 4, pp. 94–102.

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Borzykh, A.A., Andreev-Andrievskiy, A.A., Kalenchuk, V.U. et al. Strategies of adaptation of small arteries in diaphragm and gastrocnemius muscle to aerobic exercise training. Hum Physiol 43, 437–445 (2017). https://doi.org/10.1134/S0362119717040053

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  • DOI: https://doi.org/10.1134/S0362119717040053

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