Skip to main content
SpringerLink
Log in

Relationship between cytokine concentrations and the level of antibodies to neuronal proteins as dependent on the severity of mercury neurotoxicity

  • Published:
Human Physiology Aims and scope Submit manuscript

Abstract

Serum levels of cytokines and antibodies (ABs) to neuronal proteins and their relationship were studied in patients with chronic mercury intoxication (CMI) varying in severity. CMI development was observed to worsen the imbalance of pro- and anti-inflammatory cytokines, and the cytokine levels proved to reflect the severity of the pathological process. The relationships (positive and negative correlations) between cytokine and neuronal AB concentrations and their dependence on the severity of neurointoxication with elemental mercury vapor were assumed to indicate that a distorted cytokine regulation of autoimmune processes plays an important role in mercury neurotoxicity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Kryzhanovskii, G.N., Magaeva, S.V., Makarov, S.V., and Sepiashvili, R.I., Neiroimmunopatologiya: Rukovodstvo (Neuroimmunopathology: Manual), Moscow, 2003.

    Google Scholar 

  2. Lychkova, A.E. and Puzikov, A.M., Serotonergic regulation of the immune system, Usp. Fiziol. Nauk, 2014, vol. 45, no. 4, p. 70.

    Google Scholar 

  3. Davydova, T.V., Fomina, V.G., Basharova, L.A., and Fedenko, A.M., Suppression of alcohol consumption in C57Bl/6 mice after intranasal administration of antiserotonin antibodies, Bull. Exp. Biol. Med., 2005, vol. 140, no. 6, p. 687.

    Article  CAS  PubMed  Google Scholar 

  4. Evseev, V.A., Antitela k neiromediatoram v mekhanizmakh neiroimmunopatologii (Antibodies to Neurotransmitters in Mechanisms of Neuroimmunopathology), Moscow: Ross. Akad. Med. Nauk, 2007.

    Google Scholar 

  5. Kukushkin, M.L., Igon’kina, S.I., Vetrile, L.A., and Evseev, V.A., The effect of antibodies to glutamate and GABA on the development of central pain syndrome, Bol’, 2007, no. 3, p. 8.

    Google Scholar 

  6. Davydova, T.V., Kolobov, V.V., Gorbatov, V.Yu., et al., Antibodies to glutamate, neurodegenerative brain damage. Prospects of immune therapy, Patogenez, 2012, vol. 10, no. 3, p. 26.

    Google Scholar 

  7. Male, D., Brostoff, J., Roth, D.B., and Roitt, I., Immunology, Elsevier, 2006, ed.7.

    Google Scholar 

  8. Poletaev, A.B., Fiziologicheskaya immunologiya (estestvennye autoantitela i problemy nanomeditsiny) (Physiological Immunology (Natural Autoantibodies and Problems of Nanomedicine), Moscow: Miklosh, 2011.

    Google Scholar 

  9. Bodienkova, G.M., Katamanova, E.V., and Boklazhenko, E.V., Diagnostic value of autoantibodies to antigens from nervous tissue in employees exposed to metallic mercury, Ross. Allergol. Zh., 2011, no. S4-1, p. 54.

    Google Scholar 

  10. Bodienkova, G.M., Boklazhenko, E.V., Kurchevenko, S.I., et al., Role of cytokines in development of occupational neurointoxications in employees at different stages of pathological process, Fundam. Issled., 2010, no. 11, p. 22.

    Google Scholar 

  11. Rukavishnikov, V.S., Lakhman, O.L., Sosedova, L.M., et al., Occupational neurointoxications: Patterns and mechanisms of formation, Med. Tr. Prom. Ekol., 2014, no. 4, p. 1.

    Google Scholar 

  12. Simbirtsev, A.A., Cytokines: Classification and biological functions, Tsitokiny Vospalenie, 2004, vol. 3, no. 2, p. 16.

    Google Scholar 

  13. Cloëz-Tayarani, I., Petit-Bertron, A.F., Venters, H.D., and Cavaillon, J.M., Differential effect of serotonin on cytokine production in lipopolysaccharide-stimulated human peripheral blood mononuclear cell: Involvement of 5-hydroxytryptamine2A receptors, Int. Immunol., 2003, vol. 15, no. 2, p. 233.

    Article  PubMed  Google Scholar 

  14. Laberge, S., Cruikshank, W.W., Beer, D.J., and Center, D.M., Secretion of IL-16 (lumphocyte chemoattractant factor) from serotonin-stimulated CD8+ T cells in vitro, J. Immunol., 1996, vol. 156, no. 1, p. 310.

    CAS  PubMed  Google Scholar 

  15. Lanzavecchia, A. and Sallusto, F., Dynamics of T lymphocyte responses: Intermediates, effectors, and memory cells, Science, 2000, vol. 290, no. 5489, p. 92.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. East Siberian Institute of Medico-Ecological Research, Angarsk, Russia

    G. M. Bodienkova & E. V. Boklazhenko

Authors
  1. G. M. Bodienkova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. V. Boklazhenko
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to G. M. Bodienkova.

Additional information

Original Russian Text © G.M. Bodienkova, E.V. Boklazhenko, 2017, published in Fiziologiya Cheloveka, 2017, Vol. 43, No. 3, pp. 111–115.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Bodienkova, G.M., Boklazhenko, E.V. Relationship between cytokine concentrations and the level of antibodies to neuronal proteins as dependent on the severity of mercury neurotoxicity. Hum Physiol 43, 334–338 (2017). https://doi.org/10.1134/S0362119717020037

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0362119717020037

Keywords

Search

Navigation