Abstract
The purpose of the study was to estimate the cardiovascular effects of simulated factors in a 520-day crewed mission to Mars, and to validate the diagnostic value of the ultrasonic investigation of microcirculation and endothelium-dependent dilation of the right brachial artery in six male volunteers at the age of 28 to 39 years. It appears that a 520-day isolation affected intracardiac hemodynamics and endothelium function more dramatically compared with a 105-day isolation, increasing the risk of atherosclerosis. These findings add insight into the “cost of human adaptation” to very long isolation.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Builov, S.P., Voronkov, Yu.I., Stepanova, G.P., et al., The effect of a 105-day experiment in isolated environment on the functional state of the cardiovascular system of the participants, Hum. Physiol., 2012, vol. 38, no. 7, pp.699.
Pull, S.L., Voronkov, Yu.I., and Vogan, K.F., Meditsinskie trebovaniya i protsedury pri otbore kosmonavtov. Sovm. ros.-amer. Izd. (Medical Requirements and Procedures for Astronaut Selection. US–Russia Co-Publication), 2004.
Girina, M.B. and Morozova, E.A., Prospects for development of high-frequency ultrasonic Doppler flowmetry, Tr. nauch.-prakt. konf. “Metody issledovaniya regionarnogo krovoobrashcheniya i mikrotsirkulyatsii v klinike” (Proc. Sci. Pract. Conf. “Methods for Clinical Research of Regional Blood Circulation and Microcirculation”), St. Petersburg, 2004, p. 17.
Petrishchev, N.N., Vasina, E.Yu., Korneev, N.V., et al., Sposob opredeleniya reaktivnosti sosudov mikrotsirkulyatornogo rusla i vazomotornoi funktsii endoteliya s ispol’zovaniem vysokochastotnoi dopplerografii. Meditsinskaya tekhnologiya (Method for Determining the Microcirculation Reactivity of Vessels and the Vasomotion Function of Endothelium Using High-Frequency Doppler Ultrasonography. Medicinal Technology), St. Petersburg, 2009.
Corretti, M.C., Anderson, T.J., Benjamin, E.J., et al., Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilatation of brachial artery, J. Am. Coll. Cardiol., 2002, vol. 39, no. 2, pp. 257.
Celermajer, D.S., Sorensen, K.E., Gooch, V.M., et al., Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis, Lancet, 1992, vol. 340, no. 8828, pp. 1111.
Ivanova, O.V., Balakhonova, T.V., Soboleva, G.N., et al., The state of endothelium-dependent vasodilatation of the brachial artery in patients with essential hypertension: assessment by high resolution ultrasonography, Kardiologiya, 1997, no. 7, p. 41.
Widlansky, M.E., Gokce, N., Keaney, J.F., et al., The clinical implications of endothelial dysfunction, J. Am. Coll. Cardiol., 2003, vol. 42, no. 7, pp. 1149.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © G.P. Stepanova, S.P. Buylov, A.I. Eshchenko, M.A. Skedina, Yu.I. Voronkov, 2014, published in Aviakosmicheskaya i Ekologicheskaya Meditsina, 2014, Vol. 48, No. 4, pp. 23–27.
Rights and permissions
About this article
Cite this article
Stepanova, G.P., Buylov, S.P., Eshchenko, A.I. et al. Effects of the 520-day isolation on the functional state of the cardiovascular system. Hum Physiol 42, 777–781 (2016). https://doi.org/10.1134/S0362119716070161
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S0362119716070161