Skip to main content
SpringerLink
Log in

Osteoclast-activating system in cosmonauts after long-term international space station missions

  • Experimental and Theoretical Studies
  • Published:
Human Physiology Aims and scope Submit manuscript

Abstract

The results of studying the system of the osteoprotegerin/receptor activator of nuclear factor kappa-B ligand (OPG/RANKL) in 22 Russian cosmonauts after long-term (124–199 days) International Space Station missions are presented. It was found that early readaptation period is associated with changes in the serum concentrations of OPG and RANKL and the production rate of OPG and RANKL in phytohemagglutinin (PHA)-stimulated and non-stimulated mononuclear cells of peripheral blood in vitro. The extent of these changes varied in different subjects. Our data suggest that the OPG/RANKL cytokine system takes part in the processes of bone remodeling in cosmonauts after long-term missions.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Grigor'ev, A.I., Volozhin, A.I., and Stupakov, G.P., Mineral metabolism in human under conditions of altered gravitation, in Problemy kosmicheskoi biologii (Problems of Space Biology), vol. 74, Natochin, Yu.V., Ed., Moscow: Nauka, 1994

    Google Scholar 

  2. Gazenko, O.G., Grigor’ev, A.I., and Egorov, A.D., Physiological effects of weightlessness on man under conditions of space flight, Fiziol. Chel., 1997, vol. 23, no. 2, pp. 138.

    CAS  Google Scholar 

  3. Oganov, V.S., Kostnaya sistema, nevesomost' i osteoporoz (The Skeletal System, Weightlessness, and Osteoporosis), Moscow, 2003.

    Google Scholar 

  4. Oganov, V.S. and Bogomolov, V.V., The human skeletal system in weightlessness: a review of research data, hypotheses, and the possibility of predicting the state in long-term (interplanetary) missions, Hum. Physiol., 2011, vol. 37, no. 7, pp. 768.

    Article  Google Scholar 

  5. Oganov, V.S. and Grigoriev, A.I., On mechanisms of osteopenia and specific features of metabolism of human bony tissue under conditions of weightlessness, Ross. Fiziol. Zh. im. I. M. Sechenova, 2012, vol. 98, no. 3, pp. 91.

    Google Scholar 

  6. Raggatt, L.J. and Partridge, N.C., Cellular and molecular mechanisms of bone remodeling, J. Biol. Chem., 2010, vol. 285, no. 33, pp. 25103.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Umland, E.M., An update on osteoporosis epidemiology and bone physiology, Univ. Tenn. Adv. Stud. Pharm., 2008, vol. 5, no. 7, pp. 210.

    Google Scholar 

  8. Sagalovsky, S. and Schonert, M., RANKL-RANKOPG system and bone remodeling: a new approach on the treatment of osteoporosis, Clin. Exp. Pathol., 2011, vol. 10, no. 2, pp. 146.

    Google Scholar 

  9. Hsu, H., Lacey, D.L., Dunstan, C.R., et al., Tumor necrosis factor receptor family member rank mediates osteoclast differentiation and activation induced by osteoprotegerin ligand, Proc. Natl. Acad. Sci. U. S. A., 1999, vol. 96, no. 7, pp. 3540.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Schneeweis, L.A., Willard, D., and Milla, M.E., Functional dissociation of osteoprotegerin and its interaction with receptor activator of NF-kB ligand, J. Biol. Chem., 2005, vol. 280, no. 41, pp. 155.

    Google Scholar 

  11. Lacey, D.L., Tinims, E., Tan, H.L., et al., Osteoprotegerin ligand is cytokine that regulated osteoclact differentiation and activation, Cell, 1998, vol. 93, no. 2, pp. 165.

    Article  CAS  PubMed  Google Scholar 

  12. Leibbrandt, A. and Penninger, J.M., RANK/RANKL: regulators of immune responses and bone physiology, Ann. N. Y. Acad. Sci., 2008, vol. 1143, p. 124.

    Article  Google Scholar 

  13. Anandarajah, A.P., Role of RANKL in bone diseases, Trends Endocrinol. Metab., 2009, vol. 20, no. 2, pp. 88.

    Article  CAS  PubMed  Google Scholar 

  14. Kearns, A.E., Khosla, S., and Kostenuik, P.J., Receptor activator of nuclear factor kB ligand and osteoprotegerin regulation of bone remodeling in health and disease, Endocr. Rev., 2008, vol. 29, no. 2, pp. 155.

    Article  CAS  PubMed  Google Scholar 

  15. Vega, D., Maalouf, N.M., and Sakhaee, K., The role of receptor activator of nuclear factor kB (RANK) RANK-ligand/osteoprotegerin: clinical implications, J. Clin. Endocrinol. Metab., 2007, vol. 92, no. 12, pp. 4514.

    Article  CAS  PubMed  Google Scholar 

  16. Boyce, B.F. and Xing, L., Biology of RANK, RANKL, and osteoprotegerin, Arthritis Res. Ther., 2007, vol. 9, suppl. 1, p. 1.

    Article  Google Scholar 

  17. Miki, T. and Naka, H., Metabolic markers of bonepostguideline, Nippon Rinsho, 2006, vol. 64, no. 9, pp. 1625.

    PubMed  Google Scholar 

  18. Caillot-Augusseau, A., Lafage-Proust, M.H., Soler, C., et al., Bone formation and resorption biological markers in cosmonauts during and after a 180-day space flight (Euromir 95), Clin. Chem., 1998, vol. 44, no. 3, pp. 578.

    CAS  PubMed  Google Scholar 

  19. Smith, S.M., Nillen, J.L., Leblanc, A., et al., Collagen cross-link excretion during space flight and bed rest, J. Clin. Endocrinol. Metab., 1998, vol. 83, no. 10, pp. 3584.

    CAS  PubMed  Google Scholar 

  20. Caillot-Augusseau, A., Vico, L., Heer, M., et al., Space flight is associated with rapid decreases of undercarboxylated osteocalcin and increases of markers of bone resorption without changes in their circadian variation: observations in two cosmonauts, J. Clin. Endocrinol. Metab., 2000, vol. 46, no. 8, pp. 1136.

    CAS  Google Scholar 

  21. Smith, S.M., Wastney, M.E., Morukov, B.V., et al., Calcium metabolism before, during, and after a 3-mo spaceflight: kinetic and biochemical changes, Am. J. Physiol., 1999, vol. 277, no. 1, p. R1.

    Article  CAS  PubMed  Google Scholar 

  22. Smith, S.M., Wastney, M.E., O’Brien, K.O., et al., Bone markers, calcium metabolism, and calcium kinetics during extended-duration space flight on the Mir space station, J. Bone Miner. Res, 2005, vol. 20, no. 2, pp. 208.

    Article  CAS  PubMed  Google Scholar 

  23. Morukov, B.V., Nichiporuk, I.A., Tret’yakov, V.S., and Larina, I.M., Biochemical markers of bone tissue metabolism in cosmonauts after a prolonged spaceflight, Hum. Physiol., 2005, vol. 31, no. 6, pp. 684.

    Article  CAS  Google Scholar 

  24. Halleen, J.M., Tiitinen, S.L., Ylipahkala, H., et al., Tartrate-resistant acid phosphatase 5b (TRACP 5b) as a marker of bone resorption, Clin. Lab., 2006, vol. 52, nos. 9–10, p. 499.

    CAS  PubMed  Google Scholar 

  25. Dolgov, V.V. and Ermakova, I.P., Laboratory diagnostics of the exchange of minerals and bone disease, Osteoporoz Osteopatii, 2000, no. 3, p. 41.

    Google Scholar 

  26. Korovina, N.A. and Svintsitskaya, V.I., Osteopenia variants in tubulointerstitial kidney diseases in children, Pediatriya, 2010, no. 6, p. 12.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, 123007, Russia

    I. B. Morukov, M. P. Rykova, E. N. Antropova, T. A. Berendeeva, S. A. Ponomarev & B. V. Morukov

Authors
  1. I. B. Morukov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. P. Rykova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. N. Antropova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. T. A. Berendeeva
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S. A. Ponomarev
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. B. V. Morukov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M. P. Rykova.

Additional information

Original Russian Text © I.B. Morukov, M.P. Rykova, E.N. Antropova, T.A. Berendeeva, S.A. Ponomarev, B.V. Morukov, 2014, published in Aviakosmicheskaya i Ekologicheskaya Meditsina, 2014, Vol. 48, No. 6, pp. 10–15.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Morukov, I.B., Rykova, M.P., Antropova, E.N. et al. Osteoclast-activating system in cosmonauts after long-term international space station missions. Hum Physiol 42, 719–723 (2016). https://doi.org/10.1134/S0362119716070124

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0362119716070124

Keywords

Search

Navigation