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Comprehensive assessment of the hemostasis system in the participants of the Mars-500 experiment

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Abstract

Hemostasis has been studied in the course of long-term (520 days) isolation in hermetic chamber. Measured parameters included activated partial thromboplastin time (APTT), international normalized ratio (INR), thrombin time (ТT); concentrations of fibrinogen (FBG), plasminogen (PG), Willebrand factor (WF), tissue factor pathway inhibitor (TFPI), tissue plasminogen activator (TPA), and thrombomodulin (ТМ); activities of the coagulation cascade factors II, V, VII, X, VIII, IX, XI, and XII, antithrombin III (ATIII), protein С (PC), С1-inhibitor (С1), α2-antiplasmin (АP), TPA and TFPI. The investigation revealed a diversity of changes in plasma FBG concentration, slower blood coagulation in the intrinsic pathway and in final stage, and a relative rise in the activities of ATIII and PC-inhibited factors. The remaining parameters exhibited different trends.

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Authors and Affiliations

  1. Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, 123007, Russia

    D. S. Kuzichkin, A. A. Markin, A. L. Vorontsov, B. V. Morukov, O. A. Zhuravleva, I. V. Zabolotskaya & L. V. Vostrikova

Authors
  1. D. S. Kuzichkin
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  2. A. A. Markin
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  3. A. L. Vorontsov
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  4. B. V. Morukov
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  5. O. A. Zhuravleva
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  6. I. V. Zabolotskaya
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  7. L. V. Vostrikova
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Correspondence to D. S. Kuzichkin.

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Original Russian Text © D.S. Kuzichkin, A.A. Markin, A.L. Vorontsov, B.V. Morukov, O.A. Zhuravleva, I.V. Zabolotskaya, L.V. Vostrikova, 2015, published in Aviakosmicheskaya i Ekologicheskaya Meditsina, 2015, Vol. 49, No. 3, pp. 19–24.

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Kuzichkin, D.S., Markin, A.A., Vorontsov, A.L. et al. Comprehensive assessment of the hemostasis system in the participants of the Mars-500 experiment. Hum Physiol 42, 782–787 (2016). https://doi.org/10.1134/S0362119716070082

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  • DOI: https://doi.org/10.1134/S0362119716070082

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