Abstract
Ultrasonic examinations of eight male volunteers during bed rest in the antiorthostatic position (ANOP) at–15° showed plethora in the venous system of the abdominal cavity and slow blood flow through the liver with no effect on biochemical parameters. The 13C-methcetine breath test (13C-MBT) with 100 mg of 13C-methoxymethacetine showed diminution of the metabolic capacity and decline in the rate of detoxification activity of the liver due to functional changes related to hemodynamic alterations in ANOP. 13C-MBT can be used as a noninvasive method for diagnosing functional changes in the liver induced by hemodynamic reorganization in microgravity and other states triggering similar hemodynamic mechanisms.
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Original Russian Text © B.V. Afonin, E.A. Sedova, G.A. Tikhonova, A.A. Solovieva, V.A. Valuev, 2014, published in Aviakosmicheskaya i Ekologicheskaya Meditsina, 2014, Vol. 48, No. 4, pp. 17–22.
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Afonin, B.V., Sedova, E.A., Tikhonova, G.A. et al. Evaluation of the liver functional changes in modeling the hemodynamic effects of microgravity in bed rest studies. Hum Physiol 42, 747–751 (2016). https://doi.org/10.1134/S0362119716070021
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DOI: https://doi.org/10.1134/S0362119716070021