Abstract
The results of study on the sleep–wakefulness cycle in experimental models of the preclinical and early clinical stages of Parkinson’s disease are presented and compared with clinical examples. The conclusion is made that the enhancement of behavioral activity and decrease in the total duration of the slow-wave and paradoxical sleep in model animals occur at the same circadian period of the secretion of pineal melatonin as sleep disorders in patients.
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Original Russian Text © V.M. Kovalzon, M.V. Ugrumov, T.S. Pronina, V.B. Dorokhov, A.I. Manolov, V.V. Dolgikh, Y.V. Ukraintseva, L.S. Moiseenko, M.G. Poluektov, A.L. Kalinkin, 2015, published in Fiziologiya Cheloveka, 2015, Vol. 41, No. 6, pp. 114–118.
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Kovalzon, V.M., Ugrumov, M.V., Pronina, T.S. et al. Early stages of Parkinson’s disease: comparative characteristics of sleep–wakefulness cycle in patients and model animals. Hum Physiol 41, 667–671 (2015). https://doi.org/10.1134/S0362119715040106
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DOI: https://doi.org/10.1134/S0362119715040106