Skip to main content
SpringerLink
Log in

Neurophysiological features of perception to emotional stimuli in norm and patients with paranoid

  • Published:
Human Physiology Aims and scope Submit manuscript

Abstract

The latencies and amplitudes of the P100 and N170 components of event related potentials (ERPs) upon presentation of neutral and threatening visual stimuli have been studied in healthy persons and patients with schizophrenia. The studied patients had acute psychosis with a predominance of hallucinatory-paranoid syndrome and did not receive antipsychotic therapy, i.e. when the disturbances of sensory perception were mostly pronounced. Analysis of early component P100 and intermediate one N170 of event relative potentials (ERPs) in the control group healthy showed the increase of excitation to emotionally threatening stimuli; at all sites the amplitude increased and the latency shortened. In the group of patients with schizophrenia, the analysis of components P100 and N170, in contrast, showed the increased latency and decreased amplitude. The obtained data point to pathological inhibition underlying the ERPs to emotionally significant stimuli.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Jaspers, K., Allgemeine Psychopathologie: Ein Leitfaden für Studierende, Ärzte und Psychologen, Berlin: Springer, 1913.

    Google Scholar 

  2. Kring, A.M. and Moran, E.K., Emotional response deficits in schizophrenia: Insights from affective science, Schizophrenia Bull., 2008, vol. 34, p. 819.

    Article  Google Scholar 

  3. Fatemi, S.H. and Folsom, T.D., The neurodevelopmental hypothesis of schizophrenia, revisited, Schizophrenia Bull., 2009, vol. 35, no. 3, p. 528.

    Article  Google Scholar 

  4. Cacioppo, J.T., Tassinary, L.G., and Berntson, G.G., The Handbook of Psychophysiolocy, Campridge: Campridge Univ. Press, 2007.

    Book  Google Scholar 

  5. Ivanitskii, A.M., Strelets, V.B., and Korsakov, I.A., Informatsionnye protsessy mozga i psikhicheskaya deyatel’nost' (Information Processes in the Brain and Mental Activity), Moscow: Nauka, 1984.

    Google Scholar 

  6. Ivanitskii, A.M., Mozgovye mekhanizmy otsenki signalov (Cerebral Mechanisms of Signal Assessment), Moscow: Meditsina, 1976.

    Google Scholar 

  7. Leutin, V.P. and Nikolaeva, E.I., Funktsional’naya asimmetriya mozga (Functional Asymmetry of the Brain), St. Petersburg: Rech’, 2008.

    Google Scholar 

  8. Debruille, J.B., Kumar, N., Saheb, D., et al., Circumventing the deficit of context processing in schizophrenia: An event-related brain potential study, Int. J. Psychophysiol., 2010, vol. 75, no. 2, p. 167.

    Article  PubMed  Google Scholar 

  9. Kikuchi, M., Koenig, T., Wada, Y., et al., Native EEG and treatment effects in neuroleptic-naïve schizophrenic patients: time and frequency domain approaches, Schizophrenia Res., 2007, vol. 97, p. 163.

    Article  Google Scholar 

  10. Olofsson, J.K., Nordin, S., Sequeira, H., et al., Affective picture processing: An integrative review of ERP findings, Biol. Psychol., 2008, vol. 77, no. 3, p. 247.

    Article  PubMed Central  PubMed  Google Scholar 

  11. Novototsky-Vlasov, V.Yu., Garah, Zh.V., and Kovalev, V.P., A method for repetitive artifact suppression in multichannel EEG recordings, Hum. Physiol., 2007, vol. 33, no. 2, p. 231.

    Article  Google Scholar 

  12. Strelets, V.B., Mapping brain bioelectric potentials in emotional and cognitive pathologies, Zh. Vyssh. Nervn. Deyat. im. I.P. Pavlova, 1997, vol. 47, no. 2, p. 226.

    CAS  Google Scholar 

  13. Verkhlyutov, V.M., Shchuchkin, Yu.V, Ushakov, V.L., et al., Estimation of the locatiions and dipole moments of the sources of EEG α and θ rhythms by means of cluster analysis in healthy subjects and schizophrenic patients, Zh. Vyssh. Nervn. Deyat. im. I.P. Pavlova, 2006, vol. 56, no. 1, p. 47.

    Google Scholar 

  14. Luck, S.J., Mathalon, D.H., O’ Donnell B.F., et al. A roadmap for the development and validation of eventrelated potential biomarkers in schizophrenia research, Biol. Psychiatry, 2011, vol. 70, p. 28.

    Article  PubMed Central  PubMed  Google Scholar 

  15. William, P. and Horan, J., Electrophysiological correlates of emotional responding in schizophrenia, Abnorm. Psychol., 2010, vol. 119, no. 1, p. 18. doi: 10.1037/a0017510.

    Article  Google Scholar 

  16. Fellinger, R., Klimesch, W., Schnakers, C., et al., Cognitive processes in disorders of consciousness as revealed by EEG time-frequency analyses, Clin. Neurophysiol., 2011, vol. 310, p. 57.

    Google Scholar 

  17. Tononi, G., Edelman, G.M., and Sporns, O., Complexity and coherency: Integrating information in the brain, Trends Cogn. Sci., 1998, vol. 2, p. 474.

    Article  CAS  PubMed  Google Scholar 

  18. Medkour, T., Walden, A.T., Burgess, A.P., and Strelets, V.B., Brain connectivity in positive and negative syndrome schizophrenia, Neuroscience, 2010, vol. 169, no. 4, p. 1779.

    Article  CAS  PubMed  Google Scholar 

  19. Spitzer, C., Haug, H.J., and Freyberger, H.J., Dissociative symptoms in schizophrenic patients with positive and negative symptoms, Psychopathology, 1997, vol. 30, no. 2, p. 67.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, 117485, Russia

    A. Y. Arkhipov & V. B. Strelets

Authors
  1. A. Y. Arkhipov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. B. Strelets
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. Y. Arkhipov.

Additional information

The article was translated by the authors.

Original Russian Text © A.Y. Arkhipov, V.B. Strelets, 2015, published in Fiziologiya Cheloveka, 2015, Vol. 41, No. 4, pp. 31–36.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Arkhipov, A.Y., Strelets, V.B. Neurophysiological features of perception to emotional stimuli in norm and patients with paranoid. Hum Physiol 41, 367–371 (2015). https://doi.org/10.1134/S0362119715040027

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0362119715040027

Keywords

Search

Navigation