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Endotoxin is a component in the pathogenesis of chronic viral diseases


The level of endotoxin and indicators of the activity of anti-endotoxin immunity (the concentration of antibodies against Re chemotype glycolipid and enterobacterial common antigen) were determined in the serum of 174 patients with persistent viral infections (with herpes simplex, hepatitis C, and human immunodeficiency viruses). In HIV-infected patients, the presence of markers of the systemic inflammatory response syndrome (interleukin IL-1β) and acquired immunodeficiency (CD4+) was also determined. Persistent viral infections have been found to be accompanied by endotoxin aggression of intestinal origin, which they cause themselves and which can induce the systemic inflammatory response syndrome. In HIV-infected patients, this syndrome is cyclic, the phase of hyperactivity alternating with immunodeficiency. Schematically, this process can be represented as the following sequence of events: HIV-mediated damage to the intestinal barrier-development of endotoxin aggression-induction the of systemic inflammatory response syndrome-immune exhaustion, which is transient and related to the duration of the virus replication cycle, i.e., with the damage to enterocytes. The use of the anti-endotoxin component (a tool for reducing the levels of endotoxin in blood) in the scheme of treatment for persistent viral infections can contribute to successful prevention of complications.

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Correspondence to M. Yu. Yakovlev.

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Original Russian Text © I.A. Anikhovskaya, A.A. Kubatiev, G.R. Khasanova, M.Yu. Yakovlev, 2015, published in Fiziologiya Cheloveka, 2015, Vol. 41, No. 3, pp. 118–126.

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Anikhovskaya, I.A., Kubatiev, A.A., Khasanova, G.R. et al. Endotoxin is a component in the pathogenesis of chronic viral diseases. Hum Physiol 41, 328–335 (2015).

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  • lipopolysaccharide
  • endotoxin aggression
  • viral iridocyclitis
  • chronic hepatitis C
  • HIV infection
  • systemic inflammatory response syndrome
  • acquired immunodeficiency syndrome