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Hypoxic stress as an activation trigger of multipotent mesenchymal stromal cells

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Abstract

Multipotent mesenchymal stromal (stem) cells (MSCs) are a heterogeneous cell population of different commitment and are actively involved in the physiological and regenerative tissue remodeling. MSC mobilization from local tissue depots and their activation at sites of tissue damage are the key issues in the study of mechanisms of MSC functional activity implementation. Short-term hypoxic stress that is considered as a constitutive feature of the damage foci, may contribute to the activation MSC potential. This review is analysed the data on the impact of short (less than 72 h) hypoxic stress ex vivo on the viability and functional activity of MSCs.

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Authors and Affiliations

  1. Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, 123007, Russia

    E. R. Andreeva, M. V. Pogodina & L. B. Buravkova

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  1. E. R. Andreeva
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  2. M. V. Pogodina
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  3. L. B. Buravkova
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Correspondence to E. R. Andreeva.

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Original Russian Text © E.R. Andreeva, M.V. Pogodina, L.B. Buravkova, 2015, published in Fiziologiya Cheloveka, 2015, Vol. 41, No. 2, pp. 123–129.

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Andreeva, E.R., Pogodina, M.V. & Buravkova, L.B. Hypoxic stress as an activation trigger of multipotent mesenchymal stromal cells. Hum Physiol 41, 218–222 (2015). https://doi.org/10.1134/S0362119715020024

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