Estimation of the parameters of the renin-angiotensin-aldosterone system, water-electrolyte metabolism, and endothelial function in newborns of women with chronic hypertension
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The parameters of the renin-angiotensin-aldosterone system (RAAS), natriuretic peptides, and markers of endothelial function in the early neonatal period and at an age of three months were estimated in 83 full-term infants of women with chronic hypertension, including 60 newborns of women with chronic hypertension of mild to moderate severity (the main group) and 23 newborns of women without hypertension (the comparison group). The levels of renin, angiotensin-II, aldosterone, natriuretic peptides, and endothelin-1 in the umbilical cord and peripheral blood were determined by enzyme-linked immunosorbent assay (ELISA); those of stable metabolites of nitrogen, by the Griess method. Newborn of women with chronic hypertension exhibited a significant elevation of the renin, angiotensin II, and brain natriuretic peptide levels at birth. A statistically significant increase in the concentration of atrial natriuretic peptide (ANP1–28) was detected in these infants on the third to fifth day of life. In addition, the infants of this group have significantly higher levels of renin, angiotensin II, and endothelin-1 and decreased levels of endogenous nitrite at the age of three months. The results of our study indicate prenatal activation of the RAAS in the fetus. The elevated RAAS activity persisted in infants of women with chronic hypertension during the first three months of life and endothelial dysfunction in these infants developing by the age of three months.
Keywordsnewborns endothelial dysfunction renin angiotensin II
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