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Orthostatic tolerance after space flight and model experiments: new approaches to evaluation and prevention

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The article reviews the basic problems of orthostatic tolerance and new impedance methods for evaluation of orthostatic tests during spaceflight and in simulated microgravity. The results indicate that orthostatic tolerance requires adequate body hydration and function of volume-regulating hormones. New pharmacological compensators of orthostatic intolerance were tested in model experiments. It was shown that desmopressin and water-salt supplements aid in retention of body fluids and electrolytes during bed rest and improve tolerance during orthostatic test. Therefore, a simultaneous control of hydration status and orthostatic tolerance can be best provided through physiologically reasonable prescription of synthetic antidiuretic hormone analogs.

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  1. Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, 123007, Russia

    V. B. Noskov

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Original Russian Text © V.B. Noskov, 2011, published in Aviakosmicheskaya i Ekologicheskaya Meditsina, 2011, Vol. 45, No. 2, pp. 16–25.

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Noskov, V.B. Orthostatic tolerance after space flight and model experiments: new approaches to evaluation and prevention. Hum Physiol 40, 704–712 (2014). https://doi.org/10.1134/S0362119714070160

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