Abstract
Comparison of bone mineral density and fatty acid (FA) blood content in nine subjects during 370-day head-down-tilt bed rest (BR) revealed correlation of the loss of femoral neck density (FND) with parameters of lipid metabolism. On day 46 of the BR, the absolute lipid content of erythrocyte membranes and blood serum were considerably decreased (by a factor of 1.5–2) compared with the baseline data. At the end of the experiment, on the contrary, the lipid content of serum was two to three times higher than the baseline value; however, the lipid content of erythrocyte membranes remained decreased in the control group until day 280 of the BR. The arachidonic acid concentration was correlated with those of prostaglandins PGE2 and PDF2α involved in the regulation of osteoclast and osteoblast activities. The mutually correlated patterns of decrease in FND and unsaturated FA contents of blood serum and erythrocyte membranes exhibited individual specificity.
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Grigor’ev, A.I., Volozhin, A.I., and Stupakov, G.P., Mineral’nyi obmen u cheloveka v usloviyakh nevesomosti, vol. 74 of Problemy kosmicheskoi biologii (Mineral Metabolism in Humans under Microgravity Conditions, vol. 74 of Problem of Space Biology), Moscow, 1994.
Larina, I.M., Hormonal regulation, Orbit. Stantsiya Mir, 2001, vol. 1, p. 603.
Limarenko, E.A., Ca2+-binding properties of palmitic and stearic acids and the role of the complex of these acids with Ca2+ in the control of mitochondrial membrane permeability, Cand. Sci. (Biol.) Dissertation, Moscow, 2003.
Mikhailov, V.V., Osnovy patologicheskoi fiziologii (Introduction to Pathological Physiology), Moscow, 2001.
Morukov, B.V., Mineral metabolism control under the conditions of prolonged hypokinesia and spaceflight, Extended Abstract of Doctoral (Med.) Dissertation, Moscow, 1999.
Naidina, V.P., Larina, I.M., Zharkovskaya, E.E., et al., Time course of prostaglandin content and some parameters of lipid metabolism in humans under the conditions of prolonged hypokinesia, Kosm. Biol. Aviakosm. Med., 1991, vol. 25, no. 5, p. 33.
Naidina, V.P., Morukov, B.V., Pepelyaev, Yu.V., et al., Interrelations between the higher fatty acid and calcium levels in human blood under the conditions of 370-day head-down-tilt bed rest, Aviakosm. Ekol. Med., 2005, no. 6, p. 27.
Naidina, V.P., Pepelyaev, Yu.V., and Buravkova, L.B., Changes in the higher fatty acid composition of blood plasma and erythrocyte membranes during long exposure of a human to hyperbaric gas medium, Hum. Physiol., 2009, vol. 35, no. 4, p. 442.
Novitskii, V.V. and Ryazantseva, N.V., Structural disorganization of the erythrocyte membrane as a typical versatile response of the body to dysregulation diseases, in Dizregulyatsionnaya patologiya (Dysregulation Pathology), Moscow, 2002, p. 395.
Noskov, V.B. and Kotov, A.N., Impedancemetric stady of the hydration state and body composition of healthy men under the conditions of head-down-tilt bed rest, Aviakosm. Ekol. Med., 2005, no. 4, p. 41.
Oganov, V.S., Kostnaya sistema, nevesomost’ i osteoporoz (The Bone System, Microgravity, and Osteoporosis), Moscow, 2003.
Oganov, V.S. and Bogomolov, V.V., The human bone system in microgravity: Review of experimental results, hypotheses, and the possibility of predicting the state during long-term (interplanetary) missions, Aviakosm. Ekol. Med., 2009, no. 1, p. 3.
Tereshina, E.V., The role of fatty acids in the development of age-related oxidative stress, Usp. Gerontol., 2007, vol. 20, no. 1, p. 59.
Titov, V.N., The endogenous system of resistance to oxidative stress: The roles of dehydroepiandrosterone and oleic fatty acid, Usp. Sovrem. Biol., 2009, vol. 129, no. 1, p. 10.
White, A., Handler, P., and Smith, E.L., Principles of Biochemistry, McGraw-Hill, 1973, 5th edition.
Chumakova, O.V., Kartamysheva, N.N., Kuznetsova, G.V., et al., Some issues of the control of phosphorus-calcium metabolism: The role of the kidney: A review, Med. Nauch. Ucheb.-Metod. Zh., 2002, no. 11, p. 157.
Yarlykova, Yu.V., The structural and functional state of the membranes of human and animal erythrocytes as affected by factors of spaceflight and model experiments, Cand. Sci. (Biol.) Dissertation, Moscow, 1997.
Chien, D., Dean, D., Sahe, A.K., et al., Malonyl-CoA content and fatty acid oxidation in rat muscle and liver in vivo, Am. J. Physiol. Endocrinol. Metab., 2000, vol. 279, p. E259.
Hamerman, D., Osteoporosis and atherosclerosis: biological linkages and the emergence of dual-purpose therapies, Q. J. Med., 2005, vol. 98, p. 467.
Sibonga, J.D., Evans, H.J., Sung, H.G., et al., Recovery of spaceflight-induced bone loss: Bone mineral density after long-duration missions as fitted with an exponential function, Bone, 2007, vol. 41, p. 973.
Theret, N., Bard, J.M., Nuttens, M.C., et al., The relationship between the phospholipid fatty acid composition of red blood cells, plasma lipids and apolipoproteins, Metabolism, 1993, vol. 42, no. 5, p. 562.
Tymochko, M.F., Aleksevich, J.L., Bobkov, J.G., et al., Oxygen balance under extreme conditions, Hypoxia Med. J., 1996, vol. 3, p. 8.
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Original Russian Text © V.P. Naidina, Yu.V. Pepelyaev, V.S. Oganov, B.V. Morukov, V.E. Novikov, 2011, published in Aviakosmicheskaya i Ekologicheskaya Meditsina, 2011, Vol. 45, No. 2, pp. 34–38.
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Naidina, V.P., Pepelyaev, Y.V., Oganov, V.S. et al. Interrelation of the changes in blood lipid content and bone mineral density in humans during 370-day bed rest. Hum Physiol 40, 773–777 (2014). https://doi.org/10.1134/S0362119714070123
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DOI: https://doi.org/10.1134/S0362119714070123