Abstract
Throughout the 105-day experiment with isolation and confinement, the energy-producing system of red blood cells did not exhibit substantial changes. A compensatory increase in G6PD activity intensified reparative processes in the cell and inhibited lipid peroxidation (LPO). The possibility of LPO activation in the erythrocyte plasma membrane can be inferred from changes in lipid and phospholipid fractions, which testifies to an increase in the membrane microviscosity on days 70 and 105 of the experiment and after its completion. On days 70 and 105, the content of erythropoietin in all test subjects decreased, which points to a reduced erythropoietic activity and a decrease in the content of hemoglobin, erythrocyte count, hematocrit value, and hemoglobin content per erythrocyte. These shifts persisted after the experiment although erythropoietin level was slightly increased on these days. The shifts were adaptive by nature while changes in biochemical values were compensatory reactions aimed at counteracting lipid peroxidation activation by emotional stresses of the experiment.
Similar content being viewed by others
References
Vaganov, P.D., Arion, V.Ya., Polishchuk, A.V., et al., Lipid and phospholipid spectrum of blood serum and cell membranes in children with the enlarged thymus gland syndrome, Med. Nauch. i ucheb.-metod. zhurn, 2004, no. 21, p. 3.
Ivanova, S.M., Blood system during and after space flight, in Orbital’naya stantsiya “Mir” (Mir Space Station), Moscow, 2002, vol. 2, p. 159.
Ivanova, S.M.., Morukov, B.V., Labetskaya, O.I., et al., Morphological and biochemical study of erythrocyte members of the crew members of the main expeditions to the International Space Station, Aviakosm. Ekol. Med., 2006, vol. 40, no. 3, p. 9.
Levina, A.A., Andreeva, A.P., and Zamchii, A.A., Determination of the concentration of ferritin in blood serum, Gematol. Transfuziol., 1994, no. 5, p. 12.
Levina, A.A., Shishkanova, Z.G., Ivanova, S.M., et al., Study of iron metabolism in humans under antiorthostatic hypokinesia, Klin. Lab. Diagn., 1998, no. 7, p. 3.
Polyakov, V.V., Ivanova, S.M., Noskov, V.B., et al., Hematological studies under conditions of long-term space flights, Aviakosm. Ekol. Med., 1998, vol. 33, no. 2, p. 9.
Shtal’, B.V., Khromatografiya v tonkikh sloyakh (Chromatography in Thin Layers), Moscow, 1965.
Yushkov, B.G., Klimin, V.G., and Kuz’min, A.I., Sosudy kostnogo mozga i regulyatsiya krovetvoreniya (Bone Marrow Vessels and Hematopoiesis Regulation), Yekaterinburg, 2004.
Beutler, M.D., Red cell metabolism, in A Manual of Biochemical Methods, London, 1971, pp. 11, 96.
Grigoriev, A.I., Maksimov, G.V., Morukov, B.V., et al., Investigation of erythrocyte shape, plasma membrane fluidity and conformation of hemoglobin hemoporphyrin under the influence of long-term space flight, J. Gravit. Physiol., 2004, vol. 11, no. 2, p. 79.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © S.M. Ivanova, B.V. Morukov, Yu.V. Yarlykova, O.I. Labetskaya, A.A. Levina, 2010, published in Aviakosmicheskaya i Ekologicheskaya Meditsina, 2010, Vol. 44, No. 4, pp. 35–39.
Rights and permissions
About this article
Cite this article
Ivanova, S.M., Morukov, B.V., Yarlykova, Y.V. et al. Morphofunctional properties of red blood cells and erythropoiesis intensity during 105-day isolation. Hum Physiol 40, 810–813 (2014). https://doi.org/10.1134/S0362119714070068
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S0362119714070068